{"type":"trials","record":{"id":27925,"source_id":"clinicaltrials-gov","external_id":"NCT07554690","title":"Photobiomodulation Laser for Reticular Pseudodrusen in Age-Related Macular Degeneration","brief_summary":"This study evaluates whether a low-energy laser treatment called photobiomodulation (PBM) can improve visual function and retinal structure in patients with age-related macular degeneration (AMD) who have reticular pseudodrusen. PBM is a non-invasive therapy that uses specific wavelengths of light to stimulate cellular activity and reduce inflammation without causing tissue damage. Participants will be randomly assigned to receive either active PBM treatment or a sham (inactive) treatment. The study will assess changes in visual performance under low-light conditions and retinal structure over a 12-month period. The goal is to determine whether PBM can slow disease progression and improve visual function in patients with early stages of AMD.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Fondazione G.B. Bietti, IRCCS","enrollment":67,"countries":["Italy"],"start_date":"2026-10-01","completion_date":"2027-12-31","last_update_date":"2026-09-04","source_url":"https://clinicaltrials.gov/study/NCT07554690","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:07.60212+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"PBM in iAMD","age_range":"50 Years","comparator":"Sham Treatment","organization":"Fondazione G.B. Bietti, IRCCS","interventions":["Photobiomodulation Therapy","Sham Photobiomodulation"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Low-Luminance Visual Acuity (LLVA) — Baseline to Month 12","Change in Low-Luminance Contrast Sensitivity (LLCS) — Baseline to Month 12","Change in Retinal Sensitivity Measured by Microperimetry — Baseline to Month 12","Change in Retinal Structure Assessed by Optical Coherence Tomography (SD-OCT) — Baseline to Month 12","Change in Fundus Autofluorescence Patterns — Baseline to Month 12","Progression to Advanced Age-Related Macular Degeneration — Up to Month 12","Change in Retinal Perfusion Density Assessed by OCT Angiography — Baseline to Month 12","Change in Vessel Length Density Assessed by OCT Angiography — Baseline to Month 12","Change in Foveal Avascular Zone Area Assessed by OCT Angiography — Baseline to Month 12","Change in Choriocapillaris Flow Deficit Assessed by OCT Angiography — Baseline to Month 12"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","source_has_results":false},"controlled_terms":["AMD - Age-Related Macular Degeneration","Photobiomodulation Therapy","Sham Photobiomodulation"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct07554690","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-10-01 to 2027-12-31","comparator":"Sham Treatment","confidence":"structured-source","population":"ALL · 50 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.800Z","intervention":["Photobiomodulation Therapy","Sham Photobiomodulation"],"participants":67,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Low-Luminance Visual Acuity (LLVA) — Baseline to Month 12","Change in Low-Luminance Contrast Sensitivity (LLCS) — Baseline to Month 12","Change in Retinal Sensitivity Measured by Microperimetry — Baseline to Month 12","Change in Retinal Structure Assessed by Optical Coherence Tomography (SD-OCT) — Baseline to Month 12","Change in Fundus Autofluorescence Patterns — Baseline to Month 12","Progression to Advanced Age-Related Macular Degeneration — Up to Month 12","Change in Retinal Perfusion Density Assessed by OCT Angiography — Baseline to Month 12","Change in Vessel Length Density Assessed by OCT Angiography — Baseline to Month 12","Change in Foveal Avascular Zone Area Assessed by OCT Angiography — Baseline to Month 12","Change in Choriocapillaris Flow Deficit Assessed by OCT Angiography — Baseline to Month 12"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/27925","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}