{"type":"trials","record":{"id":27932,"source_id":"clinicaltrials-gov","external_id":"NCT07799623","title":"Ciprofol, Propofol and Sevoflurane for Postoperative Delirium in Elderly Brain Tumor Patients","brief_summary":"This study will compare three anesthesia medicines used to put people into a deep sleep during surgery: ciprofol, propofol, and sevoflurane. All three are commonly used for general anesthesia, but they work in different ways. Ciprofol and propofol are given through a vein. Sevoflurane is breathed in as a gas. After brain tumor surgery, some older adults may develop sudden confusion and memory problems called delirium. Researchers want to learn which of these three medicines is best at preventing delirium and protecting brain function in older adults undergoing brain tumor surgery. About 381 participants aged 65 to 90 will take part. Participants will be randomly assigned to one of three groups. One group will receive ciprofol. Another group will receive propofol. The third group will receive sevoflurane. All participants will receive standard care during and after brain tumor removal. The main goal is to compare how many participants develop delirium within 7 days after surgery. Researchers will also look at how long delirium lasts, how severe it is, thinking and memory skills at 7, 30, 90, and 180 days after surgery, quality of recovery, blood pressure and heart rate during surgery, and treatment safety. Blood tests will be used to measure markers of body stress, inflammation, and nerve cell injury before surgery, 3 hours after surgery, and 1 day after surgery. Researchers will also test thinking and memory with simple questions twice a day for 7 days after surgery. Later follow-up will be done by phone at 30, 90, and 180 days after surgery. This study is designed to explore which anesthesia medicine is safest and best at protecting the brain after surgery in older adults with brain tumors. The results may help doctors choose the best anesthesia for this group of patients in the future.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","enrollment":381,"countries":["China"],"start_date":"2026-09-30","completion_date":"2027-07-03","last_update_date":"2026-09-02","source_url":"https://clinicaltrials.gov/study/NCT07799623","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:07.60212+00:00","last_seen_at":"2026-09-25T06:20:09.878+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years to 90 Years","comparator":"Propofol Group; Sevoflurane Group","organization":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","interventions":["Ciprofol","Propofol","Sevoflurane"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Incidence of Postoperative Delirium Within 7 Days After Surgery as Assessed by the Confusion Assessment Method (CAM) —…","Duration of Postoperative Delirium in Days During the First 7 Days After Surgery — Postoperative Day 1 through Day 7","Mean Daily CAM-Severity (CAM-S) Score During the First 7 Days After Surgery — Postoperative Day 1 through Day 7 (twice…","Change in Cognitive Function From Baseline as Assessed by T-MoCA at 7 Days After Surgery — Baseline (1 day before surge…","Change in Cognitive Function From Baseline as Assessed by T-MoCA at 30 Days After Surgery — Baseline (1 day before surg…","Change in Cognitive Function From Baseline as Assessed by T-MoCA at 90 Days After Surgery — Baseline (1 day before surg…","Change in Cognitive Function From Baseline as Assessed by T-MoCA at 180 Days After Surgery — Baseline (1 day before sur…","Change in Quality of Recovery From Baseline as Assessed by QoR-15 at 1 Day After Surgery — Baseline (1 day before surge…","Change in Quality of Recovery From Baseline as Assessed by QoR-15 at 3 Days After Surgery — Baseline (1 day before surg…","Maximum Richmond Agitation-Sedation Scale (RASS) Score During Post-Anesthesia Care Unit (PACU) Stay — From PACU admissi…","Time to Loss of Consciousness Following Start of Anesthesia Induction — During anesthesia induction (measured in minute…","Time to Emergence From Anesthesia After Cessation of Anesthetic Agents — From end of surgery to emergence in the PACU (…","Time to Tracheal Extubation After Cessation of Anesthetic Agents — From end of surgery to extubation in the PACU (measu…","Length of Stay in the Post-Anesthesia Care Unit (PACU) — From PACU admission to PACU discharge (measured in minutes)","Change in Mean Arterial Pressure (MAP) From Baseline at 1 Minute After Induction, at Intubation, at Dural Incision, and…","Change in Heart Rate (HR) From Baseline at 1 Minute After Induction, at Intubation, at Dural Incision, and at End of Su…","Change in Serum Superoxide Dismutase (SOD) From Baseline at 3 Hours and 1 Day After Surgery — Baseline (1 day before su…","Change in Serum Interleukin-6 (IL-6) From Baseline at 3 Hours and 1 Day After Surgery — Baseline (1 day before surgery)…","Change in Serum S100 Calcium-Binding Protein Beta (S100β) From Baseline at 3 Hours and 1 Day After Surgery — Baseline (…"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · TRIPLE","source_has_results":false},"controlled_terms":["Brain Neoplasms","Delirium - Postoperative","Ciprofol","Propofol","Sevoflurane"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: tumor.","quality_checked_at":"2026-09-25T06:20:11.344357+00:00","duplicate_cluster_key":"id:nct07799623","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-09-30 to 2027-07-03","comparator":"Propofol Group; Sevoflurane Group","confidence":"structured-source","population":"ALL · 65 Years to 90 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:09.880Z","intervention":["Ciprofol","Propofol","Sevoflurane"],"participants":381,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Incidence of Postoperative Delirium Within 7 Days After Surgery as Assessed by the Confusion Assessment Method (CAM) —…","Duration of Postoperative Delirium in Days During the First 7 Days After Surgery — Postoperative Day 1 through Day 7","Mean Daily CAM-Severity (CAM-S) Score During the First 7 Days After Surgery — Postoperative Day 1 through Day 7 (twice…","Change in Cognitive Function From Baseline as Assessed by T-MoCA at 7 Days After Surgery — Baseline (1 day before surge…","Change in Cognitive Function From Baseline as Assessed by T-MoCA at 30 Days After Surgery — Baseline (1 day before surg…","Change in Cognitive Function From Baseline as Assessed by T-MoCA at 90 Days After Surgery — Baseline (1 day before surg…","Change in Cognitive Function From Baseline as Assessed by T-MoCA at 180 Days After Surgery — Baseline (1 day before sur…","Change in Quality of Recovery From Baseline as Assessed by QoR-15 at 1 Day After Surgery — Baseline (1 day before surge…","Change in Quality of Recovery From Baseline as Assessed by QoR-15 at 3 Days After Surgery — Baseline (1 day before surg…","Maximum Richmond Agitation-Sedation Scale (RASS) Score During Post-Anesthesia Care Unit (PACU) Stay — From PACU admissi…","Time to Loss of Consciousness Following Start of Anesthesia Induction — During anesthesia induction (measured in minute…","Time to Emergence From Anesthesia After Cessation of Anesthetic Agents — From end of surgery to emergence in the PACU (…","Time to Tracheal Extubation After Cessation of Anesthetic Agents — From end of surgery to extubation in the PACU (measu…","Length of Stay in the Post-Anesthesia Care Unit (PACU) — From PACU admission to PACU discharge (measured in minutes)","Change in Mean Arterial Pressure (MAP) From Baseline at 1 Minute After Induction, at Intubation, at Dural Incision, and…","Change in Heart Rate (HR) From Baseline at 1 Minute After Induction, at Intubation, at Dural Incision, and at End of Su…","Change in Serum Superoxide Dismutase (SOD) From Baseline at 3 Hours and 1 Day After Surgery — Baseline (1 day before su…","Change in Serum Interleukin-6 (IL-6) From Baseline at 3 Hours and 1 Day After Surgery — Baseline (1 day before surgery)…","Change in Serum S100 Calcium-Binding Protein Beta (S100β) From Baseline at 3 Hours and 1 Day After Surgery — Baseline (…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cancer-and-aging","is_published":true,"match_reasons":["Title contains controlled term: tumor.","Abstract contains controlled term: tumor.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cancer and ageing","slug":"cancer-and-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/27932","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}