{"type":"trials","record":{"id":28085,"source_id":"clinicaltrials-gov","external_id":"NCT07444554","title":"High-Velocity Resistance Training for Brain Blood Flow and Cognitive Function in Older Adults","brief_summary":"The goal of this clinical trial is to learn whether a 12-week high-velocity resistance training program can improve brain blood flow and thinking skills in adults ages 60 to 79 who are at higher risk for Alzheimer's disease and related dementias. Researchers want to understand whether this type of exercise can improve how well the brain regulates blood flow during mental and physical tasks and whether those changes are linked to improvements in thinking ability. The main questions this study aims to answer are whether high-velocity resistance training improves thinking skills such as executive function and processing speed, and whether it improves how blood flow in the brain responds during cognitive testing, changes in blood pressure, and controlled breathing tasks. Participants will complete two study visits at the University of Illinois Chicago, one before the program begins and one after 12 weeks. During these visits, researchers will measure strength, muscle power, and thinking skills. Participants will also complete non-invasive testing to measure blood flow in the brain using ultrasound. During some tasks, participants will walk on a treadmill at a comfortable pace while completing thinking tests. They will wear small sensors to measure heart rate, blood pressure, and breathing. After the first visit, participants will be randomly assigned, like flipping a coin, to one of two groups. One group will take part in supervised resistance training three times per week for 12 weeks at the University of Illinois Chicago. Each session will last about 60 minutes and will be supervised by trained exercise professionals. The other group will continue their usual daily activities for 12 weeks and then return for follow-up testing. Participants in the comparison group will be offered the exercise program after they complete the final study visit. Researchers hope this study will improve understanding of how structured exercise may support brain health in older adults at risk for dementia and help guide future prevention strategies.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Illinois at Chicago","enrollment":60,"countries":[],"start_date":"2026-06-01","completion_date":"2028-05-01","last_update_date":"2026-05-05","source_url":"https://clinicaltrials.gov/study/NCT07444554","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:10.197022+00:00","last_seen_at":"2026-09-25T06:20:09.878+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years to 79 Years","comparator":"Waitlist Control (Usual Activity)","organization":"University of Illinois at Chicago","interventions":["High-Velocity Resistance Training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Executive Function Standard Score — Baseline and 12 weeks","Change in Processing Speed Standard Score — Baseline and 12 weeks","Change in Neurovascular Coupling — Baseline and 12 weeks","Change in Dynamic Cerebral Autoregulation — Baseline and 12 weeks","Change in Cerebrovascular Reactivity — Baseline and 12 weeks"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","source_has_results":false},"controlled_terms":["At Risk for AD-dementia, With Subjective Cognitive Decline","At Risk for Cognitive Decline","High-Velocity Resistance Training"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: resistance training.","quality_checked_at":"2026-09-25T06:20:11.344357+00:00","duplicate_cluster_key":"id:nct07444554","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-06-01 to 2028-05-01","comparator":"Waitlist Control (Usual Activity)","confidence":"structured-source","population":"ALL · 60 Years to 79 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:09.886Z","intervention":["High-Velocity Resistance Training"],"participants":60,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Executive Function Standard Score — Baseline and 12 weeks","Change in Processing Speed Standard Score — Baseline and 12 weeks","Change in Neurovascular Coupling — Baseline and 12 weeks","Change in Dynamic Cerebral Autoregulation — Baseline and 12 weeks","Change in Cerebrovascular Reactivity — Baseline and 12 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: resistance training.","Abstract contains controlled term: resistance training.","Source terminology contains: resistance training.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28085","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}