{"type":"trials","record":{"id":28100,"source_id":"clinicaltrials-gov","external_id":"NCT03617302","title":"Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study","brief_summary":"This study investigates the effect of dietary inorganic nitrate supplementation on 1) large elastic artery stiffness and hemodynamics and 2) cerebrovascular function in middle-aged and older adults. Participants will be randomized to consume either nitrate-containing or nitrate-depleted beetroot juice.","overall_status":"Completed","phases":["EARLY_PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"Gary L. Pierce, PhD","enrollment":16,"countries":["United States"],"start_date":"2018-11-01","completion_date":"2024-06-30","last_update_date":"2026-03-04","source_url":"https://clinicaltrials.gov/study/NCT03617302","editorial_summary":"A registered EARLY_PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:10.197022+00:00","last_seen_at":"2026-09-25T06:20:09.878+00:00","metadata":{"sex":"ALL","acronym":"INCA","age_range":"50 Years to 79 Years","comparator":"Beetroot juice; Placebo Beetroot juice","organization":"University of Iowa","interventions":["Experimental: Nitrate-containing","Placebo: Nitrate-depleted"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Carotid Artery Compliance in mm/mmHg x 10-1 — Baseline and 2 hours following nitrate-depleted placebo beetroo…","Change in Carotid Augmentation Index — Baseline and 2 hours following nitrate-depleted beetroot juice or nitrate-contai…","Change in Carotid Pulse Pressure in mmHg — Baseline and 2 hours following nitrate-depleted beetroot juice or nitrate-co…"],"design_description":"RANDOMIZED · CROSSOVER · TREATMENT · DOUBLE","source_has_results":true},"controlled_terms":["Aging","Arterial Stiffness","Endothelial Dysfunction","Hypertension","Cognitive Decline","Experimental: Nitrate-containing","Placebo: Nitrate-depleted"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: vascular aging, arterial stiffness.","quality_checked_at":"2026-09-25T06:20:11.344357+00:00","duplicate_cluster_key":"id:nct03617302","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-11-01 to 2024-06-30","comparator":"Beetroot juice; Placebo Beetroot juice","confidence":"structured-source","population":"ALL · 50 Years to 79 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:09.888Z","intervention":["Experimental: Nitrate-containing","Placebo: Nitrate-depleted"],"participants":16,"study_design":"RANDOMIZED · CROSSOVER · TREATMENT · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"EARLY_PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Carotid Artery Compliance in mm/mmHg x 10-1 — Baseline and 2 hours following nitrate-depleted placebo beetroo…","Change in Carotid Augmentation Index — Baseline and 2 hours following nitrate-depleted beetroot juice or nitrate-contai…","Change in Carotid Pulse Pressure in mmHg — Baseline and 2 hours following nitrate-depleted beetroot juice or nitrate-co…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cardiovascular-aging","is_published":true,"match_reasons":["Title contains controlled term: vascular aging, arterial stiffness.","Source terminology contains: arterial stiffness.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cardiovascular ageing","slug":"cardiovascular-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28100","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}