{"type":"trials","record":{"id":28105,"source_id":"clinicaltrials-gov","external_id":"NCT07775196","title":"Aging and Exercise Impacts on Glymphatic Function","brief_summary":"This is a prospective, interventional, non-blinded, single center research project that will recruit cognitively unimpaired subjects in the 25-55 year old and 55-75 year old range. This study will use acute aerobic exercise as a natural intervention model to increase cardiac activity which may further drive the glymphatic function. There will be no randomization, and all enrolled subjects will participate in the exercise session. Hypotheses: revealed by the multi-modal magnetic resonance imaging (MRI) approach, glymphatic dysfunction increases with age and is associated with preclinical Alzheimer's Disease (AD) pathology in cognitively unimpaired individuals. Using acute aerobic exercise as a human model, the enhancement of cerebrospinal fluid-interstitial fluid (CSF-ISF) exchange caused by elevated cardiac activity and paravascular cerebrospinal fluid (pCSF) dynamics can be validated.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Texas Southwestern Medical Center","enrollment":240,"countries":[],"start_date":"2026-12-01","completion_date":"2029-12-01","last_update_date":"2026-08-20","source_url":"https://clinicaltrials.gov/study/NCT07775196","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:10.582012+00:00","last_seen_at":"2026-09-25T06:20:12.176+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"25 Years to 75 Years","comparator":null,"organization":"University of Texas Southwestern Medical Center","interventions":["Acute Aerobic exercise"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Exercise-induced changes in heart rate (HR) — Baseline (pre-exercise), immediately post-exercise","Exercise-induced changes in cardiac output (CO) — Baseline (pre-exercise), immediately post-exercise","Exercise-induced changes in MRI measurements of pCSF dynamics — Baseline (pre-exercise), immediately post-exercise","Exercise-induced changes in MRI measurements of CSF-ISF exchange — Baseline (pre-exercise), immediately post-exercise"],"design_description":"NA · SINGLE GROUP · BASIC SCIENCE · NONE","source_has_results":false},"controlled_terms":["Aging and Exercise Impacts on Glymphatic Function","Acute Aerobic exercise"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T06:20:12.449741+00:00","duplicate_cluster_key":"id:nct07775196","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-12-01 to 2029-12-01","comparator":null,"confidence":"structured-source","population":"ALL · 25 Years to 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:12.178Z","intervention":["Acute Aerobic exercise"],"participants":240,"study_design":"NA · SINGLE GROUP · BASIC SCIENCE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Exercise-induced changes in heart rate (HR) — Baseline (pre-exercise), immediately post-exercise","Exercise-induced changes in cardiac output (CO) — Baseline (pre-exercise), immediately post-exercise","Exercise-induced changes in MRI measurements of pCSF dynamics — Baseline (pre-exercise), immediately post-exercise","Exercise-induced changes in MRI measurements of CSF-ISF exchange — Baseline (pre-exercise), immediately post-exercise"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Source terminology contains: exercise.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}},{"topic_slug":"glymphatic-clearance","is_published":true,"match_reasons":["Title contains controlled term: glymphatic.","Abstract contains controlled term: glymphatic.","Source terminology contains: glymphatic.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Glymphatic clearance","slug":"glymphatic-clearance"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28105","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}