{"type":"trials","record":{"id":28131,"source_id":"clinicaltrials-gov","external_id":"NCT04630132","title":"Renal Ageing-sarcopenia Network","brief_summary":"Frailty is a syndrome in which the accumulation of small, individually insignificant deficits leads to heightened vulnerability to adverse events and predisposes to potential catastrophic decompensation. Objective of this study is to clarify the underlying genetic and immunological mechanisms responsible of frailty condition focused on: i. nephrosclerosis ageing kidney phenotype related to salt effects on immunosystem, ii. immunological aspect of sarcopenia, iii. psychological disorder related to immunosystem activation, iv. detection of new biomarkers of frailty.","overall_status":"Unknown","phases":[],"study_type":"OBSERVATIONAL","sponsor":"IRCCS San Raffaele","enrollment":1500,"countries":["Italy"],"start_date":"2017-03-25","completion_date":"2021-03-31","last_update_date":"2020-12-11","source_url":"https://clinicaltrials.gov/study/NCT04630132","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:10.904101+00:00","last_seen_at":"2026-09-25T06:20:12.788+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":null,"organization":"IRCCS San Raffaele","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Correlation between Frailty and Klotho polymorphism, assessed by Fried Classification: non-frail (score 0), pre-frail (…","Correlation between Frailty and Klotho (KL), Adducine (ADD1, ADD2 and ADD3), Lanosterol and other polymorphisms, assess…","Correlation between Frailty and plasmatic values of endogenous ouabain, Klotho and plasma cytokines, assessed by Fried…","Creation of a multidisciplinary frailty score, based on the outcomes of the study — 3 years"],"design_description":null,"source_has_results":false},"controlled_terms":["Aging","Frailty","Hypertension","CKD"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T06:20:12.930719+00:00","duplicate_cluster_key":"id:nct04630132","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-03-25 to 2021-03-31","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:12.788Z","intervention":[],"participants":1500,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Correlation between Frailty and Klotho polymorphism, assessed by Fried Classification: non-frail (score 0), pre-frail (…","Correlation between Frailty and Klotho (KL), Adducine (ADD1, ADD2 and ADD3), Lanosterol and other polymorphisms, assess…","Correlation between Frailty and plasmatic values of endogenous ouabain, Klotho and plasma cytokines, assessed by Fried…","Creation of a multidisciplinary frailty score, based on the outcomes of the study — 3 years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"kidney-aging","is_published":true,"match_reasons":["Title contains controlled term: renal ageing.","Title supplies longevity context: ageing.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Kidney ageing","slug":"kidney-aging"}},{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Abstract contains controlled term: sarcopenia.","Title supplies longevity context: ageing.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28131","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}