{"type":"trials","record":{"id":28134,"source_id":"clinicaltrials-gov","external_id":"NCT06591897","title":"Exploration of Gender Differences in Liver Aging","brief_summary":"The liver is an important metabolic organ in the body. It participates in central metabolic activities to maintain systemic homeostasis. It is also one of the most vulnerable organs in the process of individual aging. During aging, the volume, blood flow, metabolic capacity and regenerative capacity of the liver decrease. Liver function changes with age can lead to age-related systemic susceptibility diseases. Therefore, understanding the changes of metabolism and immune function in the process of liver aging and studying the regulation mechanism of liver aging will provide an important reference for understanding the causes of increased susceptibility to liver-related diseases in the elderly population.On the other hand, gender factors also affect organ function, leading to differences in human aging and disease outcomes.At present, the omics research on liver aging is mainly based on tissue-level transcription, protein or metabolomics, and most of the conclusions are focused on hepatocytes. However, for other cell types and microenvironment interactions, people know little about the aging changes at the cellular levelBased on the current research status, this study aims to explore the gender differences in the process of liver aging, using emerging technologies such as the combination of single-cell multi-omics and spatial localization, to reveal the factors driving liver aging from a gender perspective, and to promote the development of accurate interventions for aging and aging-related diseases.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Second Affiliated Hospital, Zhejiang University, School of Medicine","enrollment":18,"countries":["China"],"start_date":"2024-09-27","completion_date":"2027-09-20","last_update_date":"2024-10-08","source_url":"https://clinicaltrials.gov/study/NCT06591897","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:11.206021+00:00","last_seen_at":"2026-09-25T06:20:13.2+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years to 80 Years","comparator":null,"organization":"Second Affiliated Hospital, Zhejiang University, School of Medicine","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Molecular and cellular characteristics during liver aging — 2027.08"],"design_description":null,"source_has_results":false},"controlled_terms":["Healthy Population"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: liver aging.","quality_checked_at":"2026-09-25T06:20:13.32569+00:00","duplicate_cluster_key":"id:nct06591897","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-09-27 to 2027-09-20","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:13.200Z","intervention":[],"participants":18,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Molecular and cellular characteristics during liver aging — 2027.08"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"liver-aging","is_published":true,"match_reasons":["Title contains controlled term: liver aging.","Abstract contains controlled term: liver aging.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Liver ageing","slug":"liver-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28134","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}