{"type":"trials","record":{"id":28143,"source_id":"clinicaltrials-gov","external_id":"NCT03730649","title":"Effect of Topical Sulforaphane on Skin Aging and With Ultraviolet and Visible Light Exposure","brief_summary":"The study is to compare the expression of both keratin 16 and 17 before and after application of sulforaphane on both photoprotected and photoexposed area, and to determine whether these findings alter skin aging as well as skin response to ultraviolet (UV) and visible light exposure.","overall_status":"Active Not Recruiting","phases":["EARLY_PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"Johns Hopkins University","enrollment":12,"countries":["United States"],"start_date":"2019-10-09","completion_date":"2027-10-01","last_update_date":"2026-09-04","source_url":"https://clinicaltrials.gov/study/NCT03730649","editorial_summary":"A registered EARLY_PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:11.819033+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years","comparator":"Sulforaphane without light challenge; Sulforaphane with light challenge","organization":"Johns Hopkins University","interventions":["Sulforaphane (broccoli sprout extract)","UV or visible light"],"registry_source":"ClinicalTrials.gov","outcome_measures":["keratin 16 presence as determined by immunofluorescence assay — Up to 6 months","keratin 17 presence as determined by immunofluorescence assay — Up to 6 months","keratin 16 fold change as determined by Reverse Transcription Polymerase Chain Reaction (RT-PCR) — Up to 6 months","keratin 17 fold change as determined by RT-PCR — Up to 6 months","keratin expression changes as determined by RT-PCR — Up to 6 months"],"design_description":"NON RANDOMIZED · PARALLEL · PREVENTION · NONE","source_has_results":false},"controlled_terms":["Skin Aging","Sulforaphane (broccoli sprout extract)","UV or visible light"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: skin aging.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct03730649","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-10-09 to 2027-10-01","comparator":"Sulforaphane without light challenge; Sulforaphane with light challenge","confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.554Z","intervention":["Sulforaphane (broccoli sprout extract)","UV or visible light"],"participants":12,"study_design":"NON RANDOMIZED · PARALLEL · PREVENTION · NONE","subject_scope":"Human clinical study registration","evidence_stage":"EARLY_PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["keratin 16 presence as determined by immunofluorescence assay — Up to 6 months","keratin 17 presence as determined by immunofluorescence assay — Up to 6 months","keratin 16 fold change as determined by Reverse Transcription Polymerase Chain Reaction (RT-PCR) — Up to 6 months","keratin 17 fold change as determined by RT-PCR — Up to 6 months","keratin expression changes as determined by RT-PCR — Up to 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: skin aging.","Abstract contains controlled term: skin aging.","Source terminology contains: skin aging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28143","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}