{"type":"trials","record":{"id":28146,"source_id":"clinicaltrials-gov","external_id":"NCT07780799","title":"Efficacy and Safety of a Topical Botanical Extract Formulation for Skin Aging","brief_summary":"This is a single-center, double-blinded, placebo-controlled, split-face, prospective clinical study to evaluate the anti-ageing efficacy and safety of a topical cosmetic formulation containing a botanical extract. 66 female subjects with dry skin were recruited. The study compares the anti-ageing benefits of a formula containing the botanical active extract versus a placebo over a 8-week application period.","overall_status":"Active Not Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"L'Oreal","enrollment":66,"countries":["China"],"start_date":"2025-10-11","completion_date":"2026-09-25","last_update_date":"2026-08-24","source_url":"https://clinicaltrials.gov/study/NCT07780799","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:11.819033+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"35 Years to 60 Years","comparator":"Placebo: Vehicle control 1; Placebo: Vehicle Control 2","organization":"L'Oreal","interventions":["Cosmetic Topical Formulation 1","Cosmetic Base of Topical Formulation 1","Cosmetic Topical Formulation 2","Cosmetic Base of Topical Formulation 2"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Instrumental Evaluation of Skin Tone, Elasticity, and Wrinkles — Baseline, Day 28, Day 56","Clinical Scoring of Facial Ageing Signs — Baseline, Day 28, and Day 56","Trans-epidermal water loss(TEWL) — Baseline, Day 28, Day 56","Skin Hydration Index — Baseline, Day 28, Day 56","Epidermal Proteomic Profile Changes — Baseline and Day 56"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","source_has_results":false},"controlled_terms":["Aging","Dry Skin","Cosmetic Topical Formulation 1","Cosmetic Base of Topical Formulation 1","Cosmetic Topical Formulation 2","Cosmetic Base of Topical Formulation 2"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: skin aging.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct07780799","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-10-11 to 2026-09-25","comparator":"Placebo: Vehicle control 1; Placebo: Vehicle Control 2","confidence":"structured-source","population":"FEMALE · 35 Years to 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.554Z","intervention":["Cosmetic Topical Formulation 1","Cosmetic Base of Topical Formulation 1","Cosmetic Topical Formulation 2","Cosmetic Base of Topical Formulation 2"],"participants":66,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Instrumental Evaluation of Skin Tone, Elasticity, and Wrinkles — Baseline, Day 28, Day 56","Clinical Scoring of Facial Ageing Signs — Baseline, Day 28, and Day 56","Trans-epidermal water loss(TEWL) — Baseline, Day 28, Day 56","Skin Hydration Index — Baseline, Day 28, Day 56","Epidermal Proteomic Profile Changes — Baseline and Day 56"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: skin aging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28146","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}