{"type":"trials","record":{"id":282,"source_id":"clinicaltrials-gov","external_id":"NCT07065643","title":"Sex Hormones as Regulators of the Age- and Sex-dependent Benefits of Caloric Restriction","brief_summary":"Obesity increases the risk of type 2 diabetes, cardiovascular disease, and certain cancers, primarily due to elevated abdominal fat storage. With nearly two-thirds of the UK population living with overweight or obesity, there is an urgent necessity for evidence-based public health guidance to promote healthy weight. Calorie deficit can facilitate weight loss and body fat reduction, leading to health benefits, such as improved blood glucose control. Current weight management advice centres on lifestyle modification, incorporating changes to diet and physical activity to support a calorie deficit. However, existing dieting recommendations fail to consider gender or age. This is a surprising oversight, as it is well established that health outcomes vary significantly between men and women across the lifespan. Further, the menopause may have an impact on fat storage linked to changes in sex…","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Aberdeen","enrollment":75,"countries":["United Kingdom"],"start_date":"2025-07-09","completion_date":"2027-12-01","last_update_date":"2025-07-18","source_url":"https://clinicaltrials.gov/study/NCT07065643","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:01.944738+00:00","last_seen_at":"2026-09-15T00:18:34.37+00:00","metadata":{"acronym":"GendAge","organization":"University of Aberdeen","source_has_results":false},"controlled_terms":[],"relevance_confidence":80,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Published automatically with 80% topic confidence after controlled-term evaluation.","quality_checked_at":"2026-09-15T02:15:56.576005+00:00","duplicate_cluster_key":"registry:nct07065643","duplicate_of_id":null,"clinical_trial_topics":[{"topic_slug":"caloric-restriction","is_published":true,"match_reasons":["Legacy trial evaluated automatically against controlled title, summary, and longevity-context rules."],"matched_fields":["title"],"relevance_score":80,"intelligence_topics":{"name":"Caloric restriction","slug":"caloric-restriction"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/282","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}