{"type":"trials","record":{"id":28324,"source_id":"clinicaltrials-gov","external_id":"NCT05300724","title":"An Observational Study of the Progression of Intermediate Age-Related Macular Degeneration","brief_summary":"This is a multicenter prospective study in participants with intermediate age-related macular degeneration (iAMD). One primary objective of this study is to assess iAMD disease progression, by the timeline and rates of conversion for high-risk iAMD at baseline to more advanced atrophic AMD stages. The other primary objective of this observational study is to assess the feasibility of measuring the rate of photoreceptor loss as a potential clinical endpoint. The study will consist of an observation period of approximately 3 years (\\~144 weeks) for participants.","overall_status":"Active Not Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Genentech, Inc.","enrollment":400,"countries":["United States","Australia","France","Germany","Israel","Italy","Puerto Rico"],"start_date":"2022-05-27","completion_date":"2027-06-30","last_update_date":"2026-09-16","source_url":"https://clinicaltrials.gov/study/NCT05300724","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:13.08831+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"HONU","age_range":"50 Years to 94 Years","comparator":null,"organization":"Genentech, Inc.","interventions":["No intervention"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Rate of Conversion from iAMD to nGA /iRORA — Baseline up to 3 years","Rate of Conversion from nGA/iRORA to cRORA/GA — Baseline up to 3 years","Rate of Photoreceptor Loss as Assessed by Spectral Domain Optical Coherence Tomography (SD-OCT) — Baseline up to 3 years"],"design_description":null,"source_has_results":false},"controlled_terms":["Age-Related Macular Degeneration","No intervention"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct05300724","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-05-27 to 2027-06-30","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years to 94 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.796Z","intervention":["No intervention"],"participants":400,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Rate of Conversion from iAMD to nGA /iRORA — Baseline up to 3 years","Rate of Conversion from nGA/iRORA to cRORA/GA — Baseline up to 3 years","Rate of Photoreceptor Loss as Assessed by Spectral Domain Optical Coherence Tomography (SD-OCT) — Baseline up to 3 years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28324","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}