{"type":"trials","record":{"id":28342,"source_id":"clinicaltrials-gov","external_id":"NCT06174038","title":"Early Age-Related Hearing Loss Investigation (EARHLI)","brief_summary":"Early Age-Related Hearing Loss Investigation (EARHLI) is a single site study that will randomize late middle age adults to either a hearing intervention (including hearing aids) or a health education intervention. Participants will be followed for 1 year. This study will provide information on reducing cognitive decline in those at risk for Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD).","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Columbia University","enrollment":150,"countries":["United States"],"start_date":"2024-08-01","completion_date":"2027-12-31","last_update_date":"2026-08-12","source_url":"https://clinicaltrials.gov/study/NCT06174038","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:13.50034+00:00","last_seen_at":"2026-09-25T06:25:04.647+00:00","metadata":{"sex":"ALL","acronym":"EARHLI","age_range":"55 Years to 75 Years","comparator":null,"organization":"Columbia University","interventions":["Hearing Intervention","Health Education Intervention"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Free and Cued Selective Reminding Test (FC-SRT) Score — Week 0, Week 28, Week 52","Delayed Recall Log Memory IIa, (DRLM) Score — Week 0, Week 28, Week 52","Digit Symbol Substitution Test, (DSST) Score — Week 0, Week 28, Week 52","Mini-Mental State Examination 2, (MMSE-2) Score — Week 0, Week 28, Week 52","Trail Making Test Part B, (TMTB) Score — Week 0, Week 28, Week 52","Activities of Daily Living for Mild Cognitive Impairment, (ADCS-ADLPI) Score — Week 0, Week 28, Week 52","Social Activity Frequency — Week 0, Week 28, Week 52","Ability to Participate in Social Roles and Activities (APSR) Score — Week 0, Week 28, Week 52","Community Integration Measure (CIM) Score — Week 0, Week 28, Week 52","Cohens Social Network Index (SNI) Score — Week 0, Week 28, Week 52","University of California Loneliness Scale (ULS) Score — Week 0, Week 28, Week 52","Brain MRI Measures — Week 0, Week 52"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","source_has_results":false},"controlled_terms":["Alzheimer Disease","Hearing Loss","Cognitive Impairment","Hearing Intervention","Health Education Intervention"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: age-related hearing loss.","quality_checked_at":"2026-09-25T06:25:07.732232+00:00","duplicate_cluster_key":"id:nct06174038","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-08-01 to 2027-12-31","comparator":null,"confidence":"structured-source","population":"ALL · 55 Years to 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:04.651Z","intervention":["Hearing Intervention","Health Education Intervention"],"participants":150,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Free and Cued Selective Reminding Test (FC-SRT) Score — Week 0, Week 28, Week 52","Delayed Recall Log Memory IIa, (DRLM) Score — Week 0, Week 28, Week 52","Digit Symbol Substitution Test, (DSST) Score — Week 0, Week 28, Week 52","Mini-Mental State Examination 2, (MMSE-2) Score — Week 0, Week 28, Week 52","Trail Making Test Part B, (TMTB) Score — Week 0, Week 28, Week 52","Activities of Daily Living for Mild Cognitive Impairment, (ADCS-ADLPI) Score — Week 0, Week 28, Week 52","Social Activity Frequency — Week 0, Week 28, Week 52","Ability to Participate in Social Roles and Activities (APSR) Score — Week 0, Week 28, Week 52","Community Integration Measure (CIM) Score — Week 0, Week 28, Week 52","Cohens Social Network Index (SNI) Score — Week 0, Week 28, Week 52","University of California Loneliness Scale (ULS) Score — Week 0, Week 28, Week 52","Brain MRI Measures — Week 0, Week 52"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"hearing-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related hearing loss.","Abstract contains controlled term: age-related hearing loss.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Hearing ageing","slug":"hearing-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28342","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}