{"type":"trials","record":{"id":28357,"source_id":"clinicaltrials-gov","external_id":"NCT03638323","title":"Age-related Hearing Loss and Lexical Disorders","brief_summary":"In France, Alzheimer's disease accounts for 70 to 80% of the causes of neurocognitive disorders, i.e. 600,000 to 800,000 patients. It is a neurodegenerative pathology that causes evolutionary cognitive dysfunction, mainly affecting memory functions. The inability to name familiar objects (lack of the word) is one of the most commonly noted symptoms at an early stage of the disease. Presbyacusis, or age-related hearing loss, is the most common sensory deficit in the elderly which is manifested socially by a progressive discomfort of verbal communication. Presbyacusis remains underdiagnosed and undertreated: 2/3 of the patients are not using hearing aid. In recent years, a link between neurocognitive disorders and hearing loss has been shown by investigating general cognition. In this study, the investigators are investigating lexical disorders.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Groupe Hospitalier de la Rochelle Ré Aunis","enrollment":46,"countries":["France"],"start_date":"2018-08-27","completion_date":"2019-01-31","last_update_date":"2026-03-19","source_url":"https://clinicaltrials.gov/study/NCT03638323","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:13.50034+00:00","last_seen_at":"2026-09-25T06:25:04.647+00:00","metadata":{"sex":"ALL","acronym":"LOOP","age_range":"65 Years","comparator":null,"organization":"Groupe Hospitalier de la Rochelle Ré Aunis","interventions":["Speech therapy"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Link Between Lack of Word and Presbycusis — at inclusion","Association Between Age and Lack of Word — at inclusion","Association Between Gender and Lack of Word — at inclusion","Association Between Study Level and Lack of Word — at inclusion","Association Between Accommodation Type and Lack of Word — at inclusion","Association Between Laterality and Lack of Word — at inclusion","Association Between Main Diagnosis and Lack of Word — at inclusion","Association Between Hearing Aid and Lack of Word — at inclusion","Association Between Speech Therapy and Lack of Word — at inclusion"],"design_description":null,"source_has_results":true},"controlled_terms":["Alzheimer Disease","Presbycusis","Lexical Syntactic Disorder","Speech therapy"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: age-related hearing loss.","quality_checked_at":"2026-09-25T06:25:07.732232+00:00","duplicate_cluster_key":"id:nct03638323","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-08-27 to 2019-01-31","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:04.656Z","intervention":["Speech therapy"],"participants":46,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Link Between Lack of Word and Presbycusis — at inclusion","Association Between Age and Lack of Word — at inclusion","Association Between Gender and Lack of Word — at inclusion","Association Between Study Level and Lack of Word — at inclusion","Association Between Accommodation Type and Lack of Word — at inclusion","Association Between Laterality and Lack of Word — at inclusion","Association Between Main Diagnosis and Lack of Word — at inclusion","Association Between Hearing Aid and Lack of Word — at inclusion","Association Between Speech Therapy and Lack of Word — at inclusion"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"hearing-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related hearing loss.","Abstract contains controlled term: age-related hearing loss.","Source terminology contains: presbycusis.","Title supplies longevity context: age-related.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Hearing ageing","slug":"hearing-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28357","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}