{"type":"trials","record":{"id":28380,"source_id":"clinicaltrials-gov","external_id":"NCT05312983","title":"Development of a Battery of Audiological Tests for the Precision Diagnosis of Age-related Hearing Loss","brief_summary":"Age-related hearing loss, or presbycusis, is caused by many genetic and environmental factors. Its prevalence poses a public health challenge of early identification and effective hearing aid treatment. However, the lack of screening and of a validated audiological test battery to diagnose an individual's needs and to guide hearing aid adjustments is a major obstacle. Furthermore, monogenic forms of hearing loss affect only one functional module of hearing. The audiological test(s) dependent on the function of this module are affected, in a progressive manner, but not the others. A previous study showed that in early onset presbycusis patients, a quarter of the subjects tested were affected by monogenic presbycusis. The collection of audiological and vestibular tests, carried out on proven monogenic presbycusis patients and compared to that of normal hearing patients, would constitute a battery of tests allowing a precision diagnosis, then developed to all forms of presbycusis in order to study if the identification of abnormal functional modules can usefully guide the diagnosis and the early fitting.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Institut Pasteur","enrollment":700,"countries":["France"],"start_date":"2022-07-28","completion_date":"2030-12-31","last_update_date":"2025-03-03","source_url":"https://clinicaltrials.gov/study/NCT05312983","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:13.50034+00:00","last_seen_at":"2026-09-25T06:25:04.647+00:00","metadata":{"sex":"ALL","acronym":"AUDIOGENAGE","age_range":"18 Years","comparator":null,"organization":"Institut Pasteur","interventions":["Audiological and vestibular tests","Blood sampling","neurocognitive self-questionnaire"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Measurement of specificity and sensitivity of the audiological test battery in participants with early-onset presbycusi…","Normative values for audiological and vestibular tests will be determined — 4 years and 6 months","Whole-exome sequencing of samples from participants with non-monogenic presbycusis — 4 years and 6 months"],"design_description":"NA · SINGLE GROUP · DIAGNOSTIC · NONE","source_has_results":false},"controlled_terms":["Presbyacusis","Audiological and vestibular tests","Blood sampling","neurocognitive self-questionnaire"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: age-related hearing loss.","quality_checked_at":"2026-09-25T06:25:07.732232+00:00","duplicate_cluster_key":"id:nct05312983","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-07-28 to 2030-12-31","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:04.661Z","intervention":["Audiological and vestibular tests","Blood sampling","neurocognitive self-questionnaire"],"participants":700,"study_design":"NA · SINGLE GROUP · DIAGNOSTIC · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Measurement of specificity and sensitivity of the audiological test battery in participants with early-onset presbycusi…","Normative values for audiological and vestibular tests will be determined — 4 years and 6 months","Whole-exome sequencing of samples from participants with non-monogenic presbycusis — 4 years and 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"hearing-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related hearing loss.","Abstract contains controlled term: age-related hearing loss, presbycusis.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Hearing ageing","slug":"hearing-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28380","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}