{"type":"trials","record":{"id":28385,"source_id":"clinicaltrials-gov","external_id":"NCT03101722","title":"Effects of Huperzine a on Presbycusis(Δ,kHz, DB,MMSE, AD)","brief_summary":"To investigate the effects of huperzine A on tinnitus suppression, hearing and cognitive function protection in patients with presbycusis-related subjective tinnitus and cognitive impairment.","overall_status":"Enrolling By Invitation","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Zhijun Bao","enrollment":60,"countries":["China"],"start_date":"2017-05-15","completion_date":"2030-09-15","last_update_date":"2024-10-01","source_url":"https://clinicaltrials.gov/study/NCT03101722","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Enrolling By Invitation. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:13.50034+00:00","last_seen_at":"2026-09-25T06:25:04.647+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":null,"organization":"Fudan University","interventions":["BTHE and Huperzine A","BETH"],"registry_source":"ClinicalTrials.gov","outcome_measures":["hearing function protection — 1 years","global cognitive function protection — 1 years","special cognitive domains:orientation to time, orientation to place, registration, attention and calculations,recall, l…","Tinnitus suppression — 1 years"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","source_has_results":false},"controlled_terms":["Presbycusis","Tinnitus","Cognitive Impairment","BTHE and Huperzine A","BETH"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: presbycusis.","quality_checked_at":"2026-09-25T06:25:07.732232+00:00","duplicate_cluster_key":"id:nct03101722","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-05-15 to 2030-09-15","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:04.662Z","intervention":["BTHE and Huperzine A","BETH"],"participants":60,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["hearing function protection — 1 years","global cognitive function protection — 1 years","special cognitive domains:orientation to time, orientation to place, registration, attention and calculations,recall, l…","Tinnitus suppression — 1 years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"hearing-aging","is_published":true,"match_reasons":["Title contains controlled term: presbycusis.","Abstract contains controlled term: presbycusis.","Source terminology contains: presbycusis.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","study type"],"relevance_score":100,"intelligence_topics":{"name":"Hearing ageing","slug":"hearing-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28385","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}