{"type":"trials","record":{"id":28529,"source_id":"clinicaltrials-gov","external_id":"NCT05786417","title":"LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions","brief_summary":"To establish the effectiveness and tolerability of standard of care anti-anginal treatment (beta-blocker and calcium channel blocker medications) in older adults with symptomatic Stable Ischemic Heart Disease (SIHD) and multiple chronic conditions (MCC).","overall_status":"Recruiting","phases":["PHASE4"],"study_type":"INTERVENTIONAL","sponsor":"Yale University","enrollment":741,"countries":["United States"],"start_date":"2023-05-10","completion_date":"2027-05-30","last_update_date":"2026-04-07","source_url":"https://clinicaltrials.gov/study/NCT05786417","editorial_summary":"A registered PHASE4 study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:15.048652+00:00","last_seen_at":"2026-09-25T06:25:30.723+00:00","metadata":{"sex":"ALL","acronym":"LIVEBETTER","age_range":"65 Years","comparator":null,"organization":"Yale University","interventions":["Clinician Discretion","Beta blocker","Calcium channel blocker"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Quality of Life assessed using EQ-5D-5L — Baseline and 45 days","Change in Persistence on medication — up to 6 months","Change in Quality of Life assessed using EQ-5D-5L — Baseline, 6 months, 12 months, 24 months","Change in Quality of Life assessed using PROMIS® Scale v1.2 - Global Health — Baseline, 45 days, 6 months, 12 months, 2…","Change in Angina Control assessed using Seattle Angina Questionnaire (SAQ) Summary Score — Baseline, 45 days, 6 months,…","Change in 6-minute walk test — Baseline and 45 days","Change in Caregiver Burden Inventory — Baseline, 45 days, 6 months, 12 months, 24 months"],"design_description":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · SINGLE","source_has_results":false},"controlled_terms":["Angina","Stable Ischemic Heart Disease","Clinician Discretion","Beta blocker","Calcium channel blocker"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: multiple chronic conditions.","quality_checked_at":"2026-09-25T06:25:35.871646+00:00","duplicate_cluster_key":"id:nct05786417","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-05-10 to 2027-05-30","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:30.733Z","intervention":["Clinician Discretion","Beta blocker","Calcium channel blocker"],"participants":741,"study_design":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE4","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Quality of Life assessed using EQ-5D-5L — Baseline and 45 days","Change in Persistence on medication — up to 6 months","Change in Quality of Life assessed using EQ-5D-5L — Baseline, 6 months, 12 months, 24 months","Change in Quality of Life assessed using PROMIS® Scale v1.2 - Global Health — Baseline, 45 days, 6 months, 12 months, 2…","Change in Angina Control assessed using Seattle Angina Questionnaire (SAQ) Summary Score — Baseline, 45 days, 6 months,…","Change in 6-minute walk test — Baseline and 45 days","Change in Caregiver Burden Inventory — Baseline, 45 days, 6 months, 12 months, 24 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"multimorbidity","is_published":true,"match_reasons":["Title contains controlled term: multiple chronic conditions.","Abstract contains controlled term: multiple chronic conditions.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Multimorbidity","slug":"multimorbidity"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28529","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}