{"type":"trials","record":{"id":28543,"source_id":"clinicaltrials-gov","external_id":"NCT06471569","title":"Role of Aging and Individual Variation in Exercise Training Responsiveness","brief_summary":"The primary purpose of this study is to assess the effects of aging on markers of physical reserve and exercise-induced adaptations in resilience in older adults who completed a structured exercise program within the last 15 years (Parent trial: STRRIDE-PD; NCT00962962). This feasibility pilot study will enroll up to 26 participants to complete a 6-month aerobic exercise intervention.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Duke University","enrollment":9,"countries":["United States"],"start_date":"2025-04-02","completion_date":"2026-05-29","last_update_date":"2026-07-13","source_url":"https://clinicaltrials.gov/study/NCT06471569","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:15.403387+00:00","last_seen_at":"2026-09-25T07:05:20.248+00:00","metadata":{"sex":"ALL","acronym":"STRRIDE IV","age_range":"60 Years to 90 Years","comparator":null,"organization":"Duke University","interventions":["Low/Mod","High/Mod","High/Vig"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Insulin Sensitivity — Baseline, early-intervention (~6 weeks), and post-intervention (~24 weeks)","Cardiorespiratory Fitness — Baseline, early-intervention (~6 weeks), and post-intervention (~24 weeks)","Perceived Global Health — Baseline, early-intervention (~6 weeks), mid-intervention (~12 weeks), and post-intervention…","Health-Related Quality of Life — Baseline, early-intervention (~6 weeks), mid-intervention (~12 weeks), and post-interv…","Metabolic Syndrome Z-Score — Baseline, early-intervention (~6 weeks), mid-intervention (~12 weeks), and post-interventi…","Body Composition — Baseline and post-intervention (~24 weeks)"],"design_description":"NON RANDOMIZED · PARALLEL · PREVENTION · NONE","source_has_results":false},"controlled_terms":["Prediabetic State","Cardiovascular Diseases","Insulin Resistance","Obesity","Low/Mod","High/Mod","High/Vig"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T07:05:30.295959+00:00","duplicate_cluster_key":"id:nct06471569","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-04-02 to 2026-05-29","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years to 90 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T07:05:20.263Z","intervention":["Low/Mod","High/Mod","High/Vig"],"participants":9,"study_design":"NON RANDOMIZED · PARALLEL · PREVENTION · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Insulin Sensitivity — Baseline, early-intervention (~6 weeks), and post-intervention (~24 weeks)","Cardiorespiratory Fitness — Baseline, early-intervention (~6 weeks), and post-intervention (~24 weeks)","Perceived Global Health — Baseline, early-intervention (~6 weeks), mid-intervention (~12 weeks), and post-intervention…","Health-Related Quality of Life — Baseline, early-intervention (~6 weeks), mid-intervention (~12 weeks), and post-interv…","Metabolic Syndrome Z-Score — Baseline, early-intervention (~6 weeks), mid-intervention (~12 weeks), and post-interventi…","Body Composition — Baseline and post-intervention (~24 weeks)"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28543","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}