{"type":"trials","record":{"id":28547,"source_id":"clinicaltrials-gov","external_id":"NCT04235309","title":"Physical Resilience: Indicators and Mechanisms in the Elderly (PRIME) Collaborative Phase 2","brief_summary":"The purpose of this study is to examine underlying physical resilience (the ability to bounce back) in response to a specific stressor (total knee replacement).","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Duke University","enrollment":297,"countries":["United States"],"start_date":"2020-02-27","completion_date":"2023-10-30","last_update_date":"2025-12-08","source_url":"https://clinicaltrials.gov/study/NCT04235309","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:15.403387+00:00","last_seen_at":"2026-09-25T06:25:37.346+00:00","metadata":{"sex":"ALL","acronym":"PRIME-Knee","age_range":"60 Years","comparator":null,"organization":"Duke University","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in musculoskeletal resiliency following orthopedic surgery as measured by physical activity (step counts) — Base…","Change in musculoskeletal resiliency following orthopedic surgery as measured by Lower Extremity Physical Activities of…","Change in musculoskeletal resiliency following orthopedic surgery as measured by PROMIS Pain Intensity — Baseline, 1 we…","Change in musculoskeletal resiliency following orthopedic surgery as measured by PROMIS Pain Interference — Baseline, 1…","Change in cognitive resiliency following orthopedic surgery as measured by 3D-CAM. — Baseline, 1 week","Change in cognitive resiliency following orthopedic surgery as measured by cognitive change index (CCI) for patient. —…","Change in cognitive resiliency following orthopedic surgery as measured by cognitive change index (CCI) for informant a…","Change in association between in vitro immune resiliency and resilient outcomes following elective orthopedic surgery.…","Change in dual task gait speed — Baseline, 6 months","Change in tissue oxygenation index (TOI) — Baseline, 6 months","Intraoperative electrocardiography (ECG) RR variability — Surgery up to three hours"],"design_description":null,"source_has_results":false},"controlled_terms":["Resilience","Aging"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: physical resilience.","quality_checked_at":"2026-09-25T06:25:38.024662+00:00","duplicate_cluster_key":"id:nct04235309","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2020-02-27 to 2023-10-30","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:37.348Z","intervention":[],"participants":297,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in musculoskeletal resiliency following orthopedic surgery as measured by physical activity (step counts) — Base…","Change in musculoskeletal resiliency following orthopedic surgery as measured by Lower Extremity Physical Activities of…","Change in musculoskeletal resiliency following orthopedic surgery as measured by PROMIS Pain Intensity — Baseline, 1 we…","Change in musculoskeletal resiliency following orthopedic surgery as measured by PROMIS Pain Interference — Baseline, 1…","Change in cognitive resiliency following orthopedic surgery as measured by 3D-CAM. — Baseline, 1 week","Change in cognitive resiliency following orthopedic surgery as measured by cognitive change index (CCI) for patient. —…","Change in cognitive resiliency following orthopedic surgery as measured by cognitive change index (CCI) for informant a…","Change in association between in vitro immune resiliency and resilient outcomes following elective orthopedic surgery.…","Change in dual task gait speed — Baseline, 6 months","Change in tissue oxygenation index (TOI) — Baseline, 6 months","Intraoperative electrocardiography (ECG) RR variability — Surgery up to three hours"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"physiological-resilience","is_published":true,"match_reasons":["Title contains controlled term: physical resilience.","Abstract contains controlled term: physical resilience.","Title supplies longevity context: elderly.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Physiological resilience","slug":"physiological-resilience"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28547","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}