{"type":"trials","record":{"id":28549,"source_id":"clinicaltrials-gov","external_id":"NCT06955676","title":"The Effects of Moderate Intensity Cycle Ergometer vs. Treadmill Training on Physiological Resilience in Older Adults","brief_summary":"Government guidelines suggest that we should all take part in approximately two and a half hours each week of moderate-intensity aerobic exercise. Older adults are particularly important as their overall health may decline as they get older. Therefore, exercising is important especially for older adults to improve heart and muscle health and functioning in carrying out tasks of daily living. The overall effects of aging on the body can make people less likely to withstand challenges to the body - this is termed 'resilience'. Although aerobic exercise is not super easy and requires continuity, it is not extremely difficult to get used to. However, we still do not know if some types of aerobic exercise are better for you than others at improving resilience. Therefore, this study will look at cycling vs walking to see if one is better at improving resilience in older adults who are 60-80 years old. You will be trained on either a treadmill or cycle ergometer and these exercise sessions will be done over 5 weeks, 3 days a week. Each session will last 40 minutes, start with warm-up and end with cool-down sessions. Assessments will include heart, lung, muscle, and memory and thinking measurements, all of which will be taken before and after the intervention period. This work will help us to better understand how we can improve exercise prescriptions for older adults to sustain their health and functioning in their daily life.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Nottingham","enrollment":36,"countries":["United Kingdom"],"start_date":"2024-06-01","completion_date":"2026-02-01","last_update_date":"2025-05-02","source_url":"https://clinicaltrials.gov/study/NCT06955676","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:15.403387+00:00","last_seen_at":"2026-09-25T07:05:20.248+00:00","metadata":{"sex":"ALL","acronym":"MICeT","age_range":"60 Years to 80 Years","comparator":"control group","organization":"University of Nottingham","interventions":["treadmill exercise","cycle ergometer exercise"],"registry_source":"ClinicalTrials.gov","outcome_measures":["The change in vastus lateralis mass — at baseline (pre-intervention) and at the week 5 (post-intervention)","The changes of muscle strength with maximum voluntary contraction of knee extension — at baseline (pre-intervention) an…","The change in cardiorespiratory fitness (CRF) capacity via the Ekblom-bak (EB) test — at baseline (pre-intervention) an…","The difference in neuromuscular function via force accuracy task — at baseline (pre-intervention) and at the week 5 (po…","The changes in functional ability via the Timed Up and Go test (TUG) — at baseline (pre-intervention) and at the week 5…","The difference between upper limb dexterity time before and after the intervention via 9-hole peg task — at baseline (p…","The changes in cognitive function via Mini-ACE — at baseline (pre-intervention) and at the week 5 (post-intervention)","The changes of muscle strength with handgrip strength — at Baseline (pre-assessment) and at the week 5 (post-assessment)","The change in cardiorespiratory fitness (CRF) capacity via 6-minute walking test (6MWT) — at baseline (pre-intervention…","The difference in neuromuscular function via balance time in The Short Physical Performance Battery (SPPB) on motion pl…","The changes in functional ability via Short Physical Performance Battery Test — at baseline (pre-intervention) and at t…"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Older People","treadmill exercise","cycle ergometer exercise"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: physiological resilience.","quality_checked_at":"2026-09-25T07:05:30.295959+00:00","duplicate_cluster_key":"id:nct06955676","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-06-01 to 2026-02-01","comparator":"control group","confidence":"structured-source","population":"ALL · 60 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T07:05:20.303Z","intervention":["treadmill exercise","cycle ergometer exercise"],"participants":36,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["The change in vastus lateralis mass — at baseline (pre-intervention) and at the week 5 (post-intervention)","The changes of muscle strength with maximum voluntary contraction of knee extension — at baseline (pre-intervention) an…","The change in cardiorespiratory fitness (CRF) capacity via the Ekblom-bak (EB) test — at baseline (pre-intervention) an…","The difference in neuromuscular function via force accuracy task — at baseline (pre-intervention) and at the week 5 (po…","The changes in functional ability via the Timed Up and Go test (TUG) — at baseline (pre-intervention) and at the week 5…","The difference between upper limb dexterity time before and after the intervention via 9-hole peg task — at baseline (p…","The changes in cognitive function via Mini-ACE — at baseline (pre-intervention) and at the week 5 (post-intervention)","The changes of muscle strength with handgrip strength — at Baseline (pre-assessment) and at the week 5 (post-assessment)","The change in cardiorespiratory fitness (CRF) capacity via 6-minute walking test (6MWT) — at baseline (pre-intervention…","The difference in neuromuscular function via balance time in The Short Physical Performance Battery (SPPB) on motion pl…","The changes in functional ability via Short Physical Performance Battery Test — at baseline (pre-intervention) and at t…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"physiological-resilience","is_published":true,"match_reasons":["Title contains controlled term: physiological resilience.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Physiological resilience","slug":"physiological-resilience"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28549","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}