{"type":"trials","record":{"id":28639,"source_id":"clinicaltrials-gov","external_id":"NCT07314658","title":"Time-restricted Eating (TRE) and Protein in Older Adults","brief_summary":"The aim this study is to investigate the effects of time-restricted eating (TRE) on body composition, muscle function and markers of metabolic health of adults over 60 years old. This study will compare different variations of TRE - with and without an additional protein. This study involves attending two study days at the University of Surrey for baseline and end-of-intervention measurement of body composition using a gold-standard dual energy x-ray absorptiometry (DEXA) scan; muscle function using hand grip strength and 30-second sit-to-stand tests; weight. A blood sample will be taken at each study visit to measure markers of lipid and glucose control, and insulin sensitivity. Participants will be randomly allocated to one of four study groups: * control group: maintain habitual dietary patterns * TRE group: fast for 16 hours overnight, eat between 12-8pm * TRE + Protein (AM): fast for 16 hours overnight, eat between 12-8pm; take a 30g plant-based protein supplement in the morning * TRE + Protein (PM): fast for 16 hours overnight, eat between 12-8pm; take a 30g plant-based protein supplement in the afternoon Participants will be asked to follow the intervention according to their allocated group for 8 weeks.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Surrey","enrollment":80,"countries":["United Kingdom"],"start_date":"2025-12-01","completion_date":"2027-07-01","last_update_date":"2026-01-02","source_url":"https://clinicaltrials.gov/study/NCT07314658","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:16.17532+00:00","last_seen_at":"2026-09-25T06:25:43.79+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":"Control","organization":"University of Surrey","interventions":["TRE","ProtAM TRE","ProtPM TRE"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change from baseline in body composition at 2 months using whole-body dual-energy x-ray absorptiometry (DEXA) — For 8 w…","Change from baseline in muscle function at 2 months — At the start and end of 8 weeks of the assigned study intervention","Change in fasting glucose control indicators — At the start and end of 8 weeks of the assigned study intervention","Change from baseline in insulin sensitivity at 2 months — At the start and end of 8 weeks of the assigned study interve…","Change from baseline in lipid metabolism at 2 months — At the start and end of 8 weeks of the assigned study interventi…","Change from baseline in diet composition at 2 months — At the start, mid-point (week 4) and end of 8 weeks of the assig…","Feasibility of the assigned TRE intervention — at the end of the 8 week intervention"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Generally Healthy Adults Over 60 Years Old","TRE","ProtAM TRE","ProtPM TRE"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: time-restricted eating.","quality_checked_at":"2026-09-25T06:25:44.537089+00:00","duplicate_cluster_key":"id:nct07314658","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-12-01 to 2027-07-01","comparator":"Control","confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:43.799Z","intervention":["TRE","ProtAM TRE","ProtPM TRE"],"participants":80,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change from baseline in body composition at 2 months using whole-body dual-energy x-ray absorptiometry (DEXA) — For 8 w…","Change from baseline in muscle function at 2 months — At the start and end of 8 weeks of the assigned study intervention","Change in fasting glucose control indicators — At the start and end of 8 weeks of the assigned study intervention","Change from baseline in insulin sensitivity at 2 months — At the start and end of 8 weeks of the assigned study interve…","Change from baseline in lipid metabolism at 2 months — At the start and end of 8 weeks of the assigned study interventi…","Change from baseline in diet composition at 2 months — At the start, mid-point (week 4) and end of 8 weeks of the assig…","Feasibility of the assigned TRE intervention — at the end of the 8 week intervention"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"time-restricted-eating","is_published":true,"match_reasons":["Title contains controlled term: time-restricted eating.","Abstract contains controlled term: time-restricted eating.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Time-restricted eating","slug":"time-restricted-eating"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28639","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}