{"type":"trials","record":{"id":28702,"source_id":"clinicaltrials-gov","external_id":"NCT07584785","title":"Mediterranean Diet and Progressive Resistance Training Effects on BMD and Bone Turnover in the Elderly","brief_summary":"This randomized controlled trial was designed to investigate the effects of progressive resistance training (PRT) combined with a Mediterranean diet on bone mineral density (BMD) and bone turnover markers (BTMs) in older adults. Participants underwent a detailed medical history assessment, clinical examination, and dietary evaluation. Individuals who met the inclusion criteria provided written informed consent prior to participation. All procedures were conducted in accordance with the Declaration of Helsinki, and the study protocol was approved by the Ethics Committee of Manouba University (no. C.S. ISSEP.KS N˚040/2024). Eligible participants were randomly allocated to either the experimental group (EXP; n = 22) or the control group (CON; n = 19). The intervention lasted 12 months. During this period, the EXP group participated in supervised PRT sessions combined with a Mediterranean diet intervention, while the CON group received no structured intervention.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Sfax","enrollment":47,"countries":["Italy"],"start_date":"2024-03-01","completion_date":"2025-03-10","last_update_date":"2026-05-28","source_url":"https://clinicaltrials.gov/study/NCT07584785","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:16.633874+00:00","last_seen_at":"2026-09-25T06:25:45.678+00:00","metadata":{"sex":"ALL","acronym":"MED-RES-BONE","age_range":"65 Years to 90 Years","comparator":"Control Group","organization":"University of Sfax","interventions":["Mediterranean Diet combined with Resistance Training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Bone Mineral Density (BMD) — Baseline and 12 months","Bone Formation Markers — Baseline and 12 months"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · NONE","source_has_results":false},"controlled_terms":["Bone Health","Osteoporosis","Mediterranean Diet combined with Resistance Training"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: mediterranean diet.","quality_checked_at":"2026-09-25T06:25:48.368501+00:00","duplicate_cluster_key":"id:nct07584785","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-03-01 to 2025-03-10","comparator":"Control Group","confidence":"structured-source","population":"ALL · 65 Years to 90 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:45.689Z","intervention":["Mediterranean Diet combined with Resistance Training"],"participants":47,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Bone Mineral Density (BMD) — Baseline and 12 months","Bone Formation Markers — Baseline and 12 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"mediterranean-diet","is_published":true,"match_reasons":["Title contains controlled term: mediterranean diet.","Abstract contains controlled term: mediterranean diet.","Source terminology contains: mediterranean diet.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Mediterranean diet","slug":"mediterranean-diet"}},{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: resistance training.","Abstract contains controlled term: resistance training.","Source terminology contains: resistance training.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28702","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}