{"type":"trials","record":{"id":28801,"source_id":"clinicaltrials-gov","external_id":"NCT07727577","title":"Cardiorespiratory Fitness and Acute High-Intensity Exercise Effects on Brain and Cognitive Function in Older Adults","brief_summary":"The goal of this clinical trial is to learn whether a single session of high-intensity interval exercise (HIIT) affects cognitive performance and brain activity in older adults, and whether cardiorespiratory fitness influences these effects. The main questions it aims to answer are: * Does a single HIIT session change performance on a task-switching test of cognitive flexibility? * Does a single HIIT session change prefrontal brain activity during cognitive testing, as measured by functional near-infrared spectroscopy (fNIRS)? * Do older adults with higher cardiorespiratory fitness show greater cognitive and brain changes in response to HIIT than those with lower fitness? Participants will: * Visit the laboratory on two separate days * Complete a sub-maximal graded exercise test during the first visit to measure cardiorespiratory fitness * Complete a single \\~30-minute HIIT cycling session during the second visit * Complete a task-switching cognitive test before and after the HIIT session * Have their brain activity monitored with fNIRS while completing the cognitive tests","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Colby-Sawyer College","enrollment":50,"countries":["United States"],"start_date":"2026-09-01","completion_date":"2028-08-01","last_update_date":"2026-08-12","source_url":"https://clinicaltrials.gov/study/NCT07727577","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:17.467898+00:00","last_seen_at":"2026-09-25T07:05:20.248+00:00","metadata":{"sex":"ALL","acronym":"ExBrain","age_range":"55 Years to 79 Years","comparator":null,"organization":"Colby-Sawyer College","interventions":["High-Intensity Interval Training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Cognitive Flexibility (Task-Switching Performance) — Immediately before (pre-exercise) and immediately after…","Change in Prefrontal Cortex Activation (fNIRS) — Immediately before (pre-exercise) and immediately after (post-exercise…","Correlation Between Cardiorespiratory Fitness (VO₂max ) and Change in Cognitive Flexibility — Baseline (Visit 1) for VO…","Correlation Between Cardiorespiratory Fitness and Change in Prefrontal Cortex Activation — Baseline (Visit 1) for VO₂ma…"],"design_description":"NA · SINGLE GROUP · BASIC SCIENCE · NONE","source_has_results":false},"controlled_terms":["Healthy Aging","Cognitive Benefits","Cardio Respiratory Fitness","Brain Activity","High-Intensity Interval Training"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: exercise, cardiorespiratory fitness.","quality_checked_at":"2026-09-25T07:05:30.295959+00:00","duplicate_cluster_key":"id:nct07727577","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-09-01 to 2028-08-01","comparator":null,"confidence":"structured-source","population":"ALL · 55 Years to 79 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T07:05:20.258Z","intervention":["High-Intensity Interval Training"],"participants":50,"study_design":"NA · SINGLE GROUP · BASIC SCIENCE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Cognitive Flexibility (Task-Switching Performance) — Immediately before (pre-exercise) and immediately after…","Change in Prefrontal Cortex Activation (fNIRS) — Immediately before (pre-exercise) and immediately after (post-exercise…","Correlation Between Cardiorespiratory Fitness (VO₂max ) and Change in Cognitive Flexibility — Baseline (Visit 1) for VO…","Correlation Between Cardiorespiratory Fitness and Change in Prefrontal Cortex Activation — Baseline (Visit 1) for VO₂ma…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"aerobic-fitness","is_published":true,"match_reasons":["Title contains controlled term: cardiorespiratory fitness.","Abstract contains controlled term: cardiorespiratory fitness.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Aerobic fitness and VO2 max","slug":"aerobic-fitness"}},{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise, cardiorespiratory fitness.","Abstract contains controlled term: exercise, cardiorespiratory fitness.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28801","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}