{"type":"trials","record":{"id":28803,"source_id":"clinicaltrials-gov","external_id":"NCT06507189","title":"Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX)","brief_summary":"Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments that compromise healthspan and quality of life. Exercise is a multipotent treatment with promise to mitigate most aging hallmarks, but there is substantial variability in exercisƒe responsiveness. Combining endurance and resistance training in alignment with public health guidelines will be used to better understand variable exercise responsiveness in older adults with the ultimate goal of improving each older adult's capacity to attain the many health benefits of exercise.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Florida Institute for Human and Machine Cognition","enrollment":250,"countries":["United States"],"start_date":"2025-01-27","completion_date":"2029-08-31","last_update_date":"2026-08-10","source_url":"https://clinicaltrials.gov/study/NCT06507189","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:17.467898+00:00","last_seen_at":"2026-09-25T07:05:20.248+00:00","metadata":{"sex":"ALL","acronym":"M3AX","age_range":"60 Years","comparator":null,"organization":"Florida Institute for Human and Machine Cognition","interventions":["Combined endurance and resistance training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Cardiorespiratory fitness (CRF) — 23 weeks","Functional muscle quality (fMQ) — 23 weeks","Balance — 23 weeks","Cognitive performance — 23 weeks","Body composition — 23 weeks","Metabolic health — 23 weeks"],"design_description":"RANDOMIZED · FACTORIAL · TREATMENT · DOUBLE","source_has_results":false},"controlled_terms":["Aging","Aging Well","Combined endurance and resistance training"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T07:05:30.295959+00:00","duplicate_cluster_key":"id:nct06507189","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-01-27 to 2029-08-31","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T07:05:20.258Z","intervention":["Combined endurance and resistance training"],"participants":250,"study_design":"RANDOMIZED · FACTORIAL · TREATMENT · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Cardiorespiratory fitness (CRF) — 23 weeks","Functional muscle quality (fMQ) — 23 weeks","Balance — 23 weeks","Cognitive performance — 23 weeks","Body composition — 23 weeks","Metabolic health — 23 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/28803","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}