{"type":"trials","record":{"id":29099,"source_id":"clinicaltrials-gov","external_id":"NCT07454616","title":"Exploratory Study on a Multi-nutrient Supplement and Exercise Program for Improving Health Markers Associated to Longevity in Pre-frail Adults","brief_summary":"Frailty is associated with biological changes in the gut microbiome and immune system, along with marked declines in physical and cognitive function, leading to an overall reduction in quality of life. Prefrailty represents an early stage where interventions may prevent or reverse these declines. This study aims to evaluate whether a 12-week combined Synbiotic enriched oral nutritional supplement and supervised exercise program can improve muscle strength and mass, gut microbiome composition, immune function, and cognitive performance in prefrail adults aged 50-80 years.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"National University of Singapore","enrollment":40,"countries":["Singapore"],"start_date":"2025-09-22","completion_date":"2026-05-08","last_update_date":"2026-03-06","source_url":"https://clinicaltrials.gov/study/NCT07454616","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:08.862442+00:00","last_seen_at":"2026-09-25T07:05:20.248+00:00","metadata":{"sex":"ALL","acronym":"RtM","age_range":"50 Years to 80 Years","comparator":null,"organization":"National University of Singapore","interventions":["Supervised exercise program","a balanced micronutrient blend"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in muscle mass measured via B- mode ultrasound — Baseline and 12 weeks","Change on Fecal Bifidobacterium level measured via stool microbiome analysis — Baseline, 6 weeks and 12 weeks","Change in cognitive performance National Institutes of Health Toolbox Cognition Battery - Fluid composite — Baseline an…","Change in the immune function (CD4+: CD8+ ratio) — Baseline, 6 weeks and 12 weeks","Change in cardiorespiratory fitness (Peak VO₂) — Baseline and 12 weeks","Change in Muscle Strength assessed using 1RM strength test — Baseline and 12 weeks","Change in Handgrip Strength Measured by Dynamometer — Baseline, 6 weeks and 12 weeks","Stool consistency, frequency and gastrointestinal tolerance — baseline, 12 weeks","Change in Biological age determined by DNAm clocks — baseline, 12 weeks","Change in advanced glycation end-products (AGEs) assessed using skin autofluorescence. — Baseline, 12 weeks","Change in inflammatory markers (IL-6, IL-10, TNF-α and IFN-γ) — Baseline, 6 weeks and 12 weeks","Change in immune function as measured by Lymphocyte/neutrophil ratio — Baseline, 6 weeks and 12 weeks","Change in blood pressure measured using SphygmoCor-XCEL — baseline, 6 weeks, 12 weeks","Change in Arterial stiffness measured via SphygmoCor-XCEL — Baseline and 12 weeks","Change in Physical Activity Levels Measured by Wearable Devices — baseline, 12 weeks","Change in heart rate measured with SphygmoCor-XCEL — Baseline, 6 weeks and 12 weeks","Change in Lean Mass measured by Dual-Energy X-ray Absorptiometry (DXA) — Baseline and 12 weeks","Change in Body Composition Measured by Bioimpedance (InBody 770) — Baseline and 12 weeks","Change in Quality of life assessed by The 36-Item Short Form Health Survey questionnaire (SF-36) — baseline, 12 weeks","Change in Quality of Life Measured by EuroQol 5-Dimensions (EQ-5D) — Baseline, 12 weeks"],"design_description":"NA · SINGLE GROUP · HEALTH SERVICES RESEARCH · NONE","source_has_results":false},"controlled_terms":["Pre-Frailty","Aging","Supervised exercise program","a balanced micronutrient blend"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T07:05:30.295959+00:00","duplicate_cluster_key":"id:nct07454616","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-09-22 to 2026-05-08","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T07:05:20.282Z","intervention":["Supervised exercise program","a balanced micronutrient blend"],"participants":40,"study_design":"NA · SINGLE GROUP · HEALTH SERVICES RESEARCH · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in muscle mass measured via B- mode ultrasound — Baseline and 12 weeks","Change on Fecal Bifidobacterium level measured via stool microbiome analysis — Baseline, 6 weeks and 12 weeks","Change in cognitive performance National Institutes of Health Toolbox Cognition Battery - Fluid composite — Baseline an…","Change in the immune function (CD4+: CD8+ ratio) — Baseline, 6 weeks and 12 weeks","Change in cardiorespiratory fitness (Peak VO₂) — Baseline and 12 weeks","Change in Muscle Strength assessed using 1RM strength test — Baseline and 12 weeks","Change in Handgrip Strength Measured by Dynamometer — Baseline, 6 weeks and 12 weeks","Stool consistency, frequency and gastrointestinal tolerance — baseline, 12 weeks","Change in Biological age determined by DNAm clocks — baseline, 12 weeks","Change in advanced glycation end-products (AGEs) assessed using skin autofluorescence. — Baseline, 12 weeks","Change in inflammatory markers (IL-6, IL-10, TNF-α and IFN-γ) — Baseline, 6 weeks and 12 weeks","Change in immune function as measured by Lymphocyte/neutrophil ratio — Baseline, 6 weeks and 12 weeks","Change in blood pressure measured using SphygmoCor-XCEL — baseline, 6 weeks, 12 weeks","Change in Arterial stiffness measured via SphygmoCor-XCEL — Baseline and 12 weeks","Change in Physical Activity Levels Measured by Wearable Devices — baseline, 12 weeks","Change in heart rate measured with SphygmoCor-XCEL — Baseline, 6 weeks and 12 weeks","Change in Lean Mass measured by Dual-Energy X-ray Absorptiometry (DXA) — Baseline and 12 weeks","Change in Body Composition Measured by Bioimpedance (InBody 770) — Baseline and 12 weeks","Change in Quality of life assessed by The 36-Item Short Form Health Survey questionnaire (SF-36) — baseline, 12 weeks","Change in Quality of Life Measured by EuroQol 5-Dimensions (EQ-5D) — Baseline, 12 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Source terminology contains: exercise.","Title supplies longevity context: longevity, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29099","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}