{"type":"trials","record":{"id":29149,"source_id":"clinicaltrials-gov","external_id":"NCT03514537","title":"Autologous Stem/Stromal Cellular Stromal Vascular Fraction (cSVF) In Frailty-Aging Processes","brief_summary":"With increasing age and health issues associated with aging, many systemic cellular and structural changes are known to occur. The intent of this trial is to determine the safety and efficacy of delivery of autologous cellular stromal vascular fraction (cSVF) to improve the quality of life and functional health. Isolation and concentration of cSVF will be documented. To acquire autologous cSVF, a 10+ teaspoon volume of subdermal adipose (fat) tissue and stroma is removed from the trunk or upper thigh area. Using a closed system with enzymatic digestion to isolate and concentrate these cells, is followed with returning these cSVF elements only via 500 cc Normal Saline delivered via peripheral vein (IV). Documentation of cellular numbers and flow cytometer viability testing is to be correlated with clinical outcomes as reported by patients and standardized Quality of Life (QoL) form tracking","overall_status":"Suspended","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Healeon Medical Inc","enrollment":200,"countries":["United States"],"start_date":"2018-03-15","completion_date":"2028-01-15","last_update_date":"2025-09-12","source_url":"https://clinicaltrials.gov/study/NCT03514537","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Suspended. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:08.862442+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":"GARM-W","age_range":"40 Years to 90 Years","comparator":null,"organization":"Healeon Medical Inc","interventions":["Microcannula harvest adipose stromal tissues","Centricyte 1000","Sterile Normal Saline IV Deployment of cSVF","Liberase","Saline Solution"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Incidence of Treatment-Emergent Adverse Events — 6 months","Changes in Weight In Pounds — Baseline and 6 months","Activity Level — baseline and 6 months","Mobility — baseline and 6 months","Fatigue — baseline and 6 months","Mobility Performance Battery — baseline and 6 months"],"design_description":"NON RANDOMIZED · PARALLEL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Frail Elderly Syndrome","Aging","Degenerative Disease","Microcannula harvest adipose stromal tissues","Centricyte 1000","Sterile Normal Saline IV Deployment of cSVF","Liberase","Saline Solution"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct03514537","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-03-15 to 2028-01-15","comparator":null,"confidence":"structured-source","population":"ALL · 40 Years to 90 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.486Z","intervention":["Microcannula harvest adipose stromal tissues","Centricyte 1000","Sterile Normal Saline IV Deployment of cSVF","Liberase","Saline Solution"],"participants":200,"study_design":"NON RANDOMIZED · PARALLEL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Incidence of Treatment-Emergent Adverse Events — 6 months","Changes in Weight In Pounds — Baseline and 6 months","Activity Level — baseline and 6 months","Mobility — baseline and 6 months","Fatigue — baseline and 6 months","Mobility Performance Battery — baseline and 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Title supplies longevity context: aging, frailty.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29149","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}