{"type":"trials","record":{"id":29175,"source_id":"clinicaltrials-gov","external_id":"NCT04763291","title":"Cardiovascular and InflammAging Study","brief_summary":"Evidence from previous studies supports a strong relationship between fruit and vegetable consumption and reduced cardiac risk. This could be mediated via improvements on blood pressure, platelet function and vascular reactivity. Certain vitamins and polyphenols found in fruits and vegetables, have antioxidant and anti-inflammatory effects and play a major role on the function of immune cells. Previous studies have also demonstrated the importance of omega-3 fatty acids on humans' health and their positive effects on the cardiovascular system and blood lipids regulation, as well as their involvement on inflammatory response. Nutritional regimens with adequate intake of micronutrients, fruit and vegetables, omega-3 fatty acids, low in sugar and saturated fats, such as the Mediterranean diet or vegetarian diets, can reduce chronic inflammation and oxidative stress and improve cardiovascular risk profile. Considering that the population's fruit and vegetable and omega-3 intakes are below recommendations, whole food-based supplements could provide an accessible form of supplementation to bridge the gap between actual and recommended intakes. This study is aiming to assess whether long-term separate ingestions of an encapsulated juice powder concentrate and a plant-based omega fatty acid supplement, or a combined ingestion of the two, can affect biomarkers of cardiovascular health, low-grade inflammation and indicators of biological aging in older adults.","overall_status":"Active Not Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Green Beat","enrollment":80,"countries":["Austria"],"start_date":"2021-09-01","completion_date":"2026-12-01","last_update_date":"2025-07-01","source_url":"https://clinicaltrials.gov/study/NCT04763291","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:08.862442+00:00","last_seen_at":"2026-09-25T06:25:45.678+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"55 Years to 80 Years","comparator":"Control group","organization":"Green Beat","interventions":["Juice Plus+ Fruit, Vegetable and Berry blends","Juice Plus+ Omega blend"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Lipid profile markers — 12 months","Hemostasis markers — 12 months","Oxidative stress markers — 12 months","Glucose metabolism — 12 months","Concentration changes in cytokines/ cytokine receptors — 12 months","Vitamin K metabolism — 12 months","mitochondrial DNA copy number (mtDNA-CN) — 12 months","Upper respiratory tract symptoms — 12 months","Quality of life Questionnaire — 12 months","Cognitive function — 12 months","Neurotrophins — 12 months"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · NONE","source_has_results":false},"controlled_terms":["Aging","Cardiovascular Diseases","Overweight or Obesity","Juice Plus+ Fruit, Vegetable and Berry blends","Juice Plus+ Omega blend"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: inflammaging.","quality_checked_at":"2026-09-25T06:25:48.368501+00:00","duplicate_cluster_key":"id:nct04763291","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-09-01 to 2026-12-01","comparator":"Control group","confidence":"structured-source","population":"ALL · 55 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:45.709Z","intervention":["Juice Plus+ Fruit, Vegetable and Berry blends","Juice Plus+ Omega blend"],"participants":80,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Lipid profile markers — 12 months","Hemostasis markers — 12 months","Oxidative stress markers — 12 months","Glucose metabolism — 12 months","Concentration changes in cytokines/ cytokine receptors — 12 months","Vitamin K metabolism — 12 months","mitochondrial DNA copy number (mtDNA-CN) — 12 months","Upper respiratory tract symptoms — 12 months","Quality of life Questionnaire — 12 months","Cognitive function — 12 months","Neurotrophins — 12 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"chronic-inflammation","is_published":true,"match_reasons":["Title contains controlled term: inflammaging.","Abstract contains controlled term: chronic inflammation.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Chronic inflammation","slug":"chronic-inflammation"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29175","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}