{"type":"trials","record":{"id":29191,"source_id":"clinicaltrials-gov","external_id":"NCT06965972","title":"The CohorFES: a Prospective Study of Frailty and Dependence","brief_summary":"Background Frailty has become a major problem for the health system, but also a window of opportunity to fight against disability through preventive strategies focused on the detection and treatment of frailty in all settings. However, no systematic strategies of screening and early detection are available in clinical settings. This project aims to identify clinical and biological phenotypic clusters that drive through the different stages of frailty and to describe the underlying mechanisms of the trajectories leading to disability and the potential for treatment. Moreover, validation of Frailty Trait Scale 5 (FTS5) will be performed as an easy model to be implemented in primary care and hospital scope. Methods/design A prospective population-based cohort will be stablished for frailty phenotyping (CohorFES). Creation of a CIBERFES Biobank where blood and urine samples from participants of CohortFES are stored for future researches. Demographic and clinical history data, anthropometric measurements, predimed questionnaire, peripheral blood biochemical variables and metabolomics were collected for each participant at baseline and every year until become frailty. Using cluster partition models (k-means and hierarchical clustering) will group together individuals with similar deficits and characteristics (frailty phenotypes). Then, by using pre-established criteria (gap and silhouette), the proposed clustering solution (belonging to given clusters) will be evaluated. Further, investigators will assess, in a longitudinal fashion, the appearance and accumulation of deficits during the study period and identifying the clusters subgroups with more rapid progression. Results will be applied to establish and compare clusters and trajectories. Finally, frailty phenotypes and patient clusters will be correlated with health outcomes such as the use of health services (both primary and secondary care), hospital admissions, and mortality. Discussion Information about clinical and biological phenotypic clusters that drive through the different stages of frailty can lead to identify potential targets that could improve the therapeutic management of these patients. In summary, from a research perspective the project aims to better understanding of the interindividual variability in clinical events that lead to frailty, dependence and finally, to death.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Parc de Salut Mar","enrollment":1500,"countries":["Spain"],"start_date":"2022-12-01","completion_date":"2035-12-31","last_update_date":"2025-05-11","source_url":"https://clinicaltrials.gov/study/NCT06965972","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:08.862442+00:00","last_seen_at":"2026-09-25T06:25:45.678+00:00","metadata":{"sex":"ALL","acronym":"COHORFES","age_range":"65 Years to 120 Years","comparator":null,"organization":"Parc de Salut Mar","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Fried phenotype — Through study completion, an average of 5 years","Frailty Trait Scale 5 ítems: 1.- walking speed test, 2.- grip strength, 3.- Physical Activity, 4- Body Mass Index (BMI)…","Electronic Frailty index — Through study completion, an average of 5 years","Bone Mineral Density — Through study completion, an average of 5 years","Abnormal peripheral blood biochemistry — Through study completion, an average of 5 years","Age — baseline","Date of Birth — baseline","Sex — baseline","Living situation — baseline","Educational level — baseline","All-cause mortality. — From baseline until the date of death from any cause, an average of 5 years","Condition diagnosis — Through study completion, an average of 5 years","Usual treatments — Through study completion, an average of 5 years","Pharmacy use — Through study completion, an average of 5 years","Loss of weight — Through study completion, an average of 5 years","Geriatric Depression Scale — Through study completion, an average of 5 years","Barthel Index — Through study completion, an average of 5 years","Lawton-Brody Instrumental Activities of Daily Living Scale — Through study completion, an average of 5 years","Pfeiffer test — Through study completion, an average of 5 years","Predimed questionnaire — Through study completion, an average of 5 years"],"design_description":null,"source_has_results":false},"controlled_terms":["Frailty Syndrome"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:25:48.368501+00:00","duplicate_cluster_key":"id:nct06965972","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-12-01 to 2035-12-31","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years to 120 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:45.712Z","intervention":[],"participants":1500,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Fried phenotype — Through study completion, an average of 5 years","Frailty Trait Scale 5 ítems: 1.- walking speed test, 2.- grip strength, 3.- Physical Activity, 4- Body Mass Index (BMI)…","Electronic Frailty index — Through study completion, an average of 5 years","Bone Mineral Density — Through study completion, an average of 5 years","Abnormal peripheral blood biochemistry — Through study completion, an average of 5 years","Age — baseline","Date of Birth — baseline","Sex — baseline","Living situation — baseline","Educational level — baseline","All-cause mortality. — From baseline until the date of death from any cause, an average of 5 years","Condition diagnosis — Through study completion, an average of 5 years","Usual treatments — Through study completion, an average of 5 years","Pharmacy use — Through study completion, an average of 5 years","Loss of weight — Through study completion, an average of 5 years","Geriatric Depression Scale — Through study completion, an average of 5 years","Barthel Index — Through study completion, an average of 5 years","Lawton-Brody Instrumental Activities of Daily Living Scale — Through study completion, an average of 5 years","Pfeiffer test — Through study completion, an average of 5 years","Predimed questionnaire — Through study completion, an average of 5 years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29191","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}