{"type":"trials","record":{"id":29204,"source_id":"clinicaltrials-gov","external_id":"NCT06628895","title":"Effect of Modified Poco-Poco Exercise to Frailty Stages, Expression of Global DNA Methylation, GDF15 and Lamin A COP","brief_summary":"The goal of this clinical trial is to know the effect of multicomponent exercise in frail elderly in community to aging hallmarks. The main question\\[s\\] it aims to answer are: 1. Do global DNA methylation levels change in elderly people in Bandung after receiving modified poco-poco exercise? 2. Do GDF15 levels change in elderly people in Bandung after they are given modified poco-poco exercise? 3. Do lamin A COP levels change in elderly people in Bandung after they are given modified poco-poco exercise? 4. Does the level of frailty in elderly people in Bandung change after they are given modified poco-poco exercise? Participants will be asked to do flexibility, balance, aerobic and strengthening exercise included in poco-poco modified exercise three times a week for 12 weeks","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Universitas Padjadjaran","enrollment":17,"countries":["Indonesia"],"start_date":"2024-09-15","completion_date":"2025-04-30","last_update_date":"2025-03-04","source_url":"https://clinicaltrials.gov/study/NCT06628895","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:08.862442+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":null,"organization":"Universitas Padjadjaran","interventions":["EXERCISE TRAINING WITH OR WITHOUT MEDICATION"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change From Baseline in Level of Global DNA Methylation in 12 Weeks — week 0 and week 12","Change From Baseline in Level of Growth Deficiency Factor (GDF15) in 12 Weeks — week 0 and week 12","Change From Baseline in Level of Lamin A (Cyclic Osteo Progenitor) COP in 12 Weeks — week 0 and week 12","Change From Baseline in Level of Frailty in 12 Weeks — week 0 and week 12"],"design_description":"NA · SINGLE GROUP · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Frail Elderly","EXERCISE TRAINING WITH OR WITHOUT MEDICATION"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: dna methylation.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct06628895","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-09-15 to 2025-04-30","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.522Z","intervention":["EXERCISE TRAINING WITH OR WITHOUT MEDICATION"],"participants":17,"study_design":"NA · SINGLE GROUP · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change From Baseline in Level of Global DNA Methylation in 12 Weeks — week 0 and week 12","Change From Baseline in Level of Growth Deficiency Factor (GDF15) in 12 Weeks — week 0 and week 12","Change From Baseline in Level of Lamin A (Cyclic Osteo Progenitor) COP in 12 Weeks — week 0 and week 12","Change From Baseline in Level of Frailty in 12 Weeks — week 0 and week 12"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"epigenetic-alterations","is_published":true,"match_reasons":["Title contains controlled term: dna methylation.","Abstract contains controlled term: dna methylation.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Epigenetic alterations","slug":"epigenetic-alterations"}},{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29204","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}