{"type":"trials","record":{"id":29229,"source_id":"clinicaltrials-gov","external_id":"NCT03256760","title":"Sleep and Healthy Aging Research for Depression (SHARE-D) Study","brief_summary":"Late-life depression is a significant public health concern, and effective interventions for prevention and treatment are needed. Insomnia and inflammation are modifiable targets for depression prevention, and this study is significant in using an experimental approach (i.e., inflammatory challenge) to probe acute inflammatory- and depression responses as a function of insomnia, which will inform identification of molecular targets for pharmacologic interventions, and improvement of insomnia treatments to prevent depression in older adults. Project","overall_status":"Completed","phases":["PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"Michael Irwin, MD","enrollment":160,"countries":["United States"],"start_date":"2017-08-23","completion_date":"2024-04-30","last_update_date":"2024-09-05","source_url":"https://clinicaltrials.gov/study/NCT03256760","editorial_summary":"A registered PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:08.862442+00:00","last_seen_at":"2026-09-25T06:00:59.325+00:00","metadata":{"sex":"ALL","acronym":"SHARE-D","age_range":"60 Years to 80 Years","comparator":"Placebo","organization":"University of California, Los Angeles","interventions":["Endotoxin","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Depressed Mood Subscale of the Profile of Mood States (POMS) — 12 hours","Depressed mood and depressive symptoms as measured by the Montgomery Asberg Depression Rating Scale (MADRS) — 8 hours","Hamilton Depression Rating Scale — 8 hours","Emotion Facial Recognition Task — about 2 hours","Emotion Intensity Task — about 2 hours","Probabilistic Reward Task — about 2 hours","Effort Expenditure for Reward Task — about 2 hours","Social Reward Task — about 2 hours","Snaith-Hamilton Pleasure Scale — 8 hours","Temporal Experience of Pleasure Scale — 8 hours"],"design_description":"RANDOMIZED · PARALLEL · OTHER · TRIPLE","source_has_results":false},"controlled_terms":["Depression in Old Age","Endotoxin","Placebo"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: sleep.","quality_checked_at":"2026-09-25T06:01:10.468881+00:00","duplicate_cluster_key":"id:nct03256760","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-08-23 to 2024-04-30","comparator":"Placebo","confidence":"structured-source","population":"ALL · 60 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:00:59.376Z","intervention":["Endotoxin","Placebo"],"participants":160,"study_design":"RANDOMIZED · PARALLEL · OTHER · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Depressed Mood Subscale of the Profile of Mood States (POMS) — 12 hours","Depressed mood and depressive symptoms as measured by the Montgomery Asberg Depression Rating Scale (MADRS) — 8 hours","Hamilton Depression Rating Scale — 8 hours","Emotion Facial Recognition Task — about 2 hours","Emotion Intensity Task — about 2 hours","Probabilistic Reward Task — about 2 hours","Effort Expenditure for Reward Task — about 2 hours","Social Reward Task — about 2 hours","Snaith-Hamilton Pleasure Scale — 8 hours","Temporal Experience of Pleasure Scale — 8 hours"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sleep","is_published":true,"match_reasons":["Title contains controlled term: sleep.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Sleep","slug":"sleep"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29229","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}