{"type":"trials","record":{"id":29231,"source_id":"clinicaltrials-gov","external_id":"NCT06582992","title":"DNA Methylation Trajectories in Aging","brief_summary":"The goal of this observational study is to profile changes in DNA methylation of circulating CD4+ T and CD8+ T cells from healthy young to aged with diagnosis of HFpEF, a particular phenotype of HF which is highly prevalent in aging. The main question it aims to answer is: -Do DNA methylation biomarkers help us to understand the role of inflammation in HFpEF during aging? Our goal is to provide a simple large-scale panel of epigenetic-sensitive biomarkers useful in aged patients with HF in the early natural history of the disease (HFpEF).","overall_status":"Unknown","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University of Campania Luigi Vanvitelli","enrollment":150,"countries":["Italy"],"start_date":"2024-11-01","completion_date":"2025-11-01","last_update_date":"2024-09-03","source_url":"https://clinicaltrials.gov/study/NCT06582992","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:08.862442+00:00","last_seen_at":"2026-09-25T06:05:37.656+00:00","metadata":{"sex":"ALL","acronym":"EPI-GERAS","age_range":"18 Years","comparator":null,"organization":"University of Campania Luigi Vanvitelli","interventions":["RRBS"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Number of differentially methylated positions and regions as assessed by RRBS — 6 months"],"design_description":null,"source_has_results":false},"controlled_terms":["Heart Failure","Aging","RRBS"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: dna methylation.","quality_checked_at":"2026-09-25T06:05:39.423355+00:00","duplicate_cluster_key":"id:nct06582992","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-11-01 to 2025-11-01","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:37.668Z","intervention":["RRBS"],"participants":150,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Number of differentially methylated positions and regions as assessed by RRBS — 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"epigenetic-alterations","is_published":true,"match_reasons":["Title contains controlled term: dna methylation.","Abstract contains controlled term: dna methylation.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Epigenetic alterations","slug":"epigenetic-alterations"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29231","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}