{"type":"trials","record":{"id":29300,"source_id":"clinicaltrials-gov","external_id":"NCT05368896","title":"Peri-operative Inflammaging in the Elderly After Surgery","brief_summary":"The population older than 80 years will significantly increase in the near future. Older patients' cognitive and physical status is known to deteriorate after surgery, leading to a high 30-day mortality due to post-operative comorbidities. Aging and related diseases share immune-related pathomechanisms. During aging, a chronic, low-grade sterile inflammation, called inflamaging, gradually develops. This likely results from low-grade innate immune activation and a functional, epigenomic and transcriptomic reprogramming of immune cells. Based on the hypothesis that surgical trauma leads to misplaced or altered self-molecules, which exacerbate inflammation and the postoperative risk for morbidity and mortality in elderly patients. There is increasing evidence that the individual's pre-operative immunobiography determines the susceptibility to peri-operative inflammation and post-operative outcome. Current exploratory pilot study will thus perform phenotyping of patients above 80 years undergoing major surgery. Participants will be evaluated for acute and long-term outcomes, including all-cause mortality, physical and cognitive function. To assess the individual's immunobiography, participants will be characterised by inflammation biomarkers combined with immunophenotyping, functional assays, and (epi-) genomic analyses before and after surgery. The cognitive impairment will be evaluated by measuring markers of neurodegeneration and neuropsychiatric testing and relate findings to volumetric imaging using high-resolution MRI to identify brain changes associated with cognitive decline.","overall_status":"Unknown","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University of Bonn","enrollment":150,"countries":["Germany"],"start_date":"2022-12-01","completion_date":"2025-03-30","last_update_date":"2023-02-28","source_url":"https://clinicaltrials.gov/study/NCT05368896","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:08.862442+00:00","last_seen_at":"2026-09-25T06:05:37.656+00:00","metadata":{"sex":"ALL","acronym":"POPIMAGE","age_range":"80 Years","comparator":null,"organization":"University of Bonn","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Peri-interventional (surgical and non-surgical interventional) all-cause mortality rate on day 30 — 30 days","In-hospital outcome according to the ACS National Surgical Quality Improvement Program® (ACS NSQIP®) — 30 days","Analysis of the new-onset of serious cardiac complications — 30 days","Analysis of the new-onset of serious pulmonary complications — 30 days","Analysis of the new-onset of acute stroke — 30 days","Analysis of the new-onset of acute kidney injury — 30 days","Unplanned intensive care unit admission — 30 days","Unplanned intubation after intervention — 30 days","Analysis of the new-onset of sepsis — 30 days","Analysis of the new-onset surgical side infection — 30 days","Ventilator dependency >48 h — 48 hours","Analysis of the new-onset thrombosis — 30 days","all cause mortality — 12 month"],"design_description":null,"source_has_results":false},"controlled_terms":["Aging","Immunology","Postoperative Complications","Surgery"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: inflammaging.","quality_checked_at":"2026-09-25T06:05:39.423355+00:00","duplicate_cluster_key":"id:nct05368896","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-12-01 to 2025-03-30","comparator":null,"confidence":"structured-source","population":"ALL · 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:37.670Z","intervention":[],"participants":150,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Peri-interventional (surgical and non-surgical interventional) all-cause mortality rate on day 30 — 30 days","In-hospital outcome according to the ACS National Surgical Quality Improvement Program® (ACS NSQIP®) — 30 days","Analysis of the new-onset of serious cardiac complications — 30 days","Analysis of the new-onset of serious pulmonary complications — 30 days","Analysis of the new-onset of acute stroke — 30 days","Analysis of the new-onset of acute kidney injury — 30 days","Unplanned intensive care unit admission — 30 days","Unplanned intubation after intervention — 30 days","Analysis of the new-onset of sepsis — 30 days","Analysis of the new-onset surgical side infection — 30 days","Ventilator dependency >48 h — 48 hours","Analysis of the new-onset thrombosis — 30 days","all cause mortality — 12 month"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"chronic-inflammation","is_published":true,"match_reasons":["Title contains controlled term: inflammaging.","Title supplies longevity context: aging, elderly.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Chronic inflammation","slug":"chronic-inflammation"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29300","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}