{"type":"trials","record":{"id":29302,"source_id":"clinicaltrials-gov","external_id":"NCT04220658","title":"Biomarker Study to Evaluate Correlations Between Epigenetic Aging and NAD+ Levels in Healthy Volunteers","brief_summary":"This is a single center, prospective study to evaluate correlations between epigenetic aging (as measured via DNA methylation) and NAD+ levels in healthy volunteers.","overall_status":"Suspended","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Elysium Health","enrollment":170,"countries":["United States"],"start_date":"2019-12-19","completion_date":"2023-12-03","last_update_date":"2023-02-15","source_url":"https://clinicaltrials.gov/study/NCT04220658","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Suspended. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:08.862442+00:00","last_seen_at":"2026-09-25T06:15:13.984+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"25 Years to 80 Years","comparator":null,"organization":"Elysium Health","interventions":["Biomarker study"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Correlation between biological age, calculated using DNA isolated from blood, and circulating NAD+ levels — At baseline","Correlations between biological age, calculated using DNA isolated from saliva, and circulating NAD+ levels — At baseli…","Correlations between biological age, calculated using DNA isolated from blood and saliva, and Omega-3 levels in blood —…"],"design_description":null,"source_has_results":false},"controlled_terms":["Epigenetics","Biomarker study"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: nad+.","quality_checked_at":"2026-09-25T06:15:15.562724+00:00","duplicate_cluster_key":"id:nct04220658","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-12-19 to 2023-12-03","comparator":null,"confidence":"structured-source","population":"ALL · 25 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:14.007Z","intervention":["Biomarker study"],"participants":170,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Correlation between biological age, calculated using DNA isolated from blood, and circulating NAD+ levels — At baseline","Correlations between biological age, calculated using DNA isolated from saliva, and circulating NAD+ levels — At baseli…","Correlations between biological age, calculated using DNA isolated from blood and saliva, and Omega-3 levels in blood —…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"nad-metabolism","is_published":true,"match_reasons":["Title contains controlled term: nad+.","Abstract contains controlled term: nad+.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"NAD metabolism","slug":"nad-metabolism"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29302","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}