{"type":"trials","record":{"id":29303,"source_id":"clinicaltrials-gov","external_id":"NCT05508191","title":"Microneedle Versus Fractional CO₂ Laser for Skin Aging Treatment With Stem Cell Secretome in Indonesian Adult Women","brief_summary":"Evidences regarding the effectiveness of adipose-derived mesenchymal stem cells (ADMSCs) secretome to alleviate skin aging have been extensively available, yet no studies hitherto directly investigated the best administration technique for such purpose. The objective of this study is to compare microneedling and fractional CO₂ laser methods in administrating ADMSCs secretome for facial skin rejuvenation of Indonesian adult women.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Shannaz Nadia Yusharyahya","enrollment":30,"countries":["Indonesia"],"start_date":"2022-08-17","completion_date":"2022-12-31","last_update_date":"2023-02-13","source_url":"https://clinicaltrials.gov/study/NCT05508191","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:08.862442+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"35 Years to 59 Years","comparator":null,"organization":"Universitas Indonesia","interventions":["Fractional CO₂ Laser","Microneedle"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Skin aging changes evaluated by dermoscopy photoaging scale (DPAS) — Week 0 (baseline), week 2 before intervention, wee…","Skin aging changes evaluated by Janus-3Ⓡ skin analyzer — Week 0 (baseline), week 2 before intervention, week 4 before i…","Skin capacitance evaluated by the CorneometerⓇ — Week 0 (baseline), week 2 before intervention, week 4 before intervent…","Transepidermal water loss evaluated by the TewameterⓇ — Week 0 (baseline), week 2 before intervention, week 4 before in…","Likert scale for the satisfaction degree — Week 6 (end of trial)","Visual analog scale (VAS) of pain for the convenience degree — Week 6 (end of trial)","Number of adverse events experienced during the clinical trial — Week 2 thirty minutes after intervention, week 4 thirt…","Subjective preference to treatment — Week 6 (end of trial)"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","source_has_results":false},"controlled_terms":["Skin Aging","Transepidermal Water Loss","Fractional CO₂ Laser","Microneedle"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: stem cell.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct05508191","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-08-17 to 2022-12-31","comparator":null,"confidence":"structured-source","population":"FEMALE · 35 Years to 59 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.589Z","intervention":["Fractional CO₂ Laser","Microneedle"],"participants":30,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Skin aging changes evaluated by dermoscopy photoaging scale (DPAS) — Week 0 (baseline), week 2 before intervention, wee…","Skin aging changes evaluated by Janus-3Ⓡ skin analyzer — Week 0 (baseline), week 2 before intervention, week 4 before i…","Skin capacitance evaluated by the CorneometerⓇ — Week 0 (baseline), week 2 before intervention, week 4 before intervent…","Transepidermal water loss evaluated by the TewameterⓇ — Week 0 (baseline), week 2 before intervention, week 4 before in…","Likert scale for the satisfaction degree — Week 6 (end of trial)","Visual analog scale (VAS) of pain for the convenience degree — Week 6 (end of trial)","Number of adverse events experienced during the clinical trial — Week 2 thirty minutes after intervention, week 4 thirt…","Subjective preference to treatment — Week 6 (end of trial)"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: skin aging.","Abstract contains controlled term: skin aging.","Source terminology contains: skin aging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}},{"topic_slug":"stem-cells","is_published":true,"match_reasons":["Title contains controlled term: stem cell.","Abstract contains controlled term: stem cell.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Stem cells","slug":"stem-cells"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29303","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}