{"type":"trials","record":{"id":29307,"source_id":"clinicaltrials-gov","external_id":"NCT04880720","title":"Deciphering a Specific Signature of the Immunosenescence Induced in COVID-19+ Patients Versus Rheumatoid Arthritis Patients","brief_summary":"Immune aging or immunosenescence is characterized by a loss of T cell clonal diversity and a contraction of naïve T cells with proliferative capacity associated with the functional impairment of many others immune cells as well as a chronic low degree of inflammation. A restrictive T cell repertoire is likely more prone to antigen-mediated exhaustion observed during chronic viral infections. Notably, lymphopenia is the most consistent laboratory abnormality in COVID-19 infected patients and both lung-resident and circulating T cells potently up-regulate markers of T cell exhaustion. It is not clear today if the association of COVID-19 disease severity with age is mainly related with the immunosenescence of infected patients. Interestingly, T cell exhaustion and premature immunosenescence have also been observed in chronic inflammatory diseases such as rheumatoid arthritis (RA). To better understand the immunological mechanisms involved in SARS-Cov-2 pathophysiology, the investigators propose to compare the immunosenescence patterns observed during RA, aging and SARS-Cov-2 infected patients in order to design improved therapeutic interventions.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University Hospital, Montpellier","enrollment":43,"countries":["France"],"start_date":"2021-07-19","completion_date":"2022-11-16","last_update_date":"2023-01-05","source_url":"https://clinicaltrials.gov/study/NCT04880720","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:08.862442+00:00","last_seen_at":"2026-09-25T06:15:06.064+00:00","metadata":{"sex":"ALL","acronym":"SENO-COVID","age_range":"18 Years","comparator":null,"organization":"University Hospital, Montpellier","interventions":["Blood sampling"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Results of phenotypic immunosenescence analyses of COVID-19 patients targeting 5 different immune populations (neutroph…","Comparison of previous results with the results of senescence immunophenotyping in peripheral blood of a reference popu…","Identification of a specific gene expression of immunosenescence induced in COVID-19 patients, using transcriptomic ana…"],"design_description":null,"source_has_results":false},"controlled_terms":["SARS-Cov-2 Infection","Rheumatoid Arthritis","Blood sampling"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: immunosenescence.","quality_checked_at":"2026-09-25T06:15:09.632521+00:00","duplicate_cluster_key":"id:nct04880720","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-07-19 to 2022-11-16","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:06.089Z","intervention":["Blood sampling"],"participants":43,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Results of phenotypic immunosenescence analyses of COVID-19 patients targeting 5 different immune populations (neutroph…","Comparison of previous results with the results of senescence immunophenotyping in peripheral blood of a reference popu…","Identification of a specific gene expression of immunosenescence induced in COVID-19 patients, using transcriptomic ana…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"immune-aging","is_published":true,"match_reasons":["Title contains controlled term: immunosenescence.","Abstract contains controlled term: immunosenescence, immune aging.","Title supplies longevity context: senescence.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Immune ageing","slug":"immune-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29307","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}