{"type":"trials","record":{"id":29358,"source_id":"clinicaltrials-gov","external_id":"NCT03457870","title":"Intermittent Energy Restriction and Chewing on Neural Stem Cell Ageing and Adult Hippocampal Neurogenesis Associated Cognition","brief_summary":"Extended bouts of periodic mastication and intermittent energy restriction (IER) may improve cognitive performance in the context of adult hippocampal neurogenesis in an ageing population. A randomised controlled parallel design trial will determine the impact of a 3 month IER diet (2 consecutive days of very low calorie diet and 5 days of normal eating) and a mastication intervention (1 piece of gum chewed for 10 minutes 3 times a day) in comparison to a control on neurogenesis-associated cognitive measures and circulating levels of the anti-ageing protein Klotho.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"King's College London","enrollment":123,"countries":["United Kingdom"],"start_date":"2018-04-18","completion_date":"2020-03-23","last_update_date":"2021-02-18","source_url":"https://clinicaltrials.gov/study/NCT03457870","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:08.862442+00:00","last_seen_at":"2026-09-25T06:05:08.502+00:00","metadata":{"sex":"FEMALE","acronym":"ChANgE","age_range":"60 Years","comparator":"Control","organization":"King's College London","interventions":["Intermittent Energy Restriction","Chewing","Chewing + Intermittent Energy Restriction"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Serum Klotho concentration — Baseline","Serum Klotho concentration — Day 42","Serum Klotho concentration — Day 84","Mnemonic Similarity Task — Baseline","Mnemonic Similarity Task — Day 42","Body weight — Baseline","Body weight — Day 42","Body weight — Day 84","Body fat percentage — Baseline","Body fat percentage — Day 42","Body fat percentage — Day 84","Body Mass Index — Baseline","Body Mass Index — Day 42","Body Mass Index — Day 84","Waist circumference — Baseline","Waist circumference — Day 42","Waist circumference — Day 84","Hip circumference — Baseline","Hip circumference — Day 42","Hip circumference — Day 84"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · NONE","source_has_results":false},"controlled_terms":["Aging","Cognitive Decline","Intermittent Energy Restriction","Chewing","Chewing + Intermittent Energy Restriction"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: stem cell.","quality_checked_at":"2026-09-25T06:05:13.559725+00:00","duplicate_cluster_key":"id:nct03457870","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-04-18 to 2020-03-23","comparator":"Control","confidence":"structured-source","population":"FEMALE · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:08.539Z","intervention":["Intermittent Energy Restriction","Chewing","Chewing + Intermittent Energy Restriction"],"participants":123,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Serum Klotho concentration — Baseline","Serum Klotho concentration — Day 42","Serum Klotho concentration — Day 84","Mnemonic Similarity Task — Baseline","Mnemonic Similarity Task — Day 42","Body weight — Baseline","Body weight — Day 42","Body weight — Day 84","Body fat percentage — Baseline","Body fat percentage — Day 42","Body fat percentage — Day 84","Body Mass Index — Baseline","Body Mass Index — Day 42","Body Mass Index — Day 84","Waist circumference — Baseline","Waist circumference — Day 42","Waist circumference — Day 84","Hip circumference — Baseline","Hip circumference — Day 42","Hip circumference — Day 84"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"stem-cells","is_published":true,"match_reasons":["Title contains controlled term: stem cell.","Title supplies longevity context: ageing.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Stem cells","slug":"stem-cells"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29358","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}