{"type":"trials","record":{"id":29415,"source_id":"clinicaltrials-gov","external_id":"NCT02999802","title":"Nutrient Sensing & Signaling in Aging Muscle","brief_summary":"This research seeks to better understand how cellular and molecular bases of changes associated with aging contribute to decreased function and increased incidence of disease. Specific mechanism in muscle responsible for anabolic resistance - a key component of sarcopenia and frailty - will be identified. The proposed research is relevant to public health because the discovery of new targets for interventions and novel therapeutics to improve muscle strength and function, prevent falls, and reduce physical dependency will improve the healthspan and quality of life in older adults by improving their physical function and ability to remain independent and healthy for a longer period of time.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"The University of Texas Medical Branch, Galveston","enrollment":19,"countries":["United States"],"start_date":"2015-10-01","completion_date":"2016-12-21","last_update_date":"2018-06-13","source_url":"https://clinicaltrials.gov/study/NCT02999802","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:08.862442+00:00","last_seen_at":"2026-09-25T06:05:31.63+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years to 80 Years","comparator":null,"organization":"The University of Texas Medical Branch, Galveston","interventions":["Exercise"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in muscle protein synthesis in response to amino acids — Change from baseline to 3 months","Muscle mass — Change from baseline to 3 months","Muscle function — Change from baseline to 3 months"],"design_description":"NA · SINGLE GROUP · BASIC SCIENCE · NONE","source_has_results":false},"controlled_terms":["Nutrient Sensing","Exercise"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: nutrient sensing.","quality_checked_at":"2026-09-25T06:05:33.370492+00:00","duplicate_cluster_key":"id:nct02999802","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2015-10-01 to 2016-12-21","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:31.648Z","intervention":["Exercise"],"participants":19,"study_design":"NA · SINGLE GROUP · BASIC SCIENCE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in muscle protein synthesis in response to amino acids — Change from baseline to 3 months","Muscle mass — Change from baseline to 3 months","Muscle function — Change from baseline to 3 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"nutrient-sensing","is_published":true,"match_reasons":["Title contains controlled term: nutrient sensing.","Source terminology contains: nutrient sensing.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Nutrient sensing","slug":"nutrient-sensing"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29415","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}