{"type":"trials","record":{"id":29419,"source_id":"clinicaltrials-gov","external_id":"NCT02116270","title":"Accelerated Immunosenescence and Chronic Kidney Disease","brief_summary":"The aim of this study is to investigate the impact of renal function and dialysis techniques on the percentage of senescent T lymphocytes.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Centre Hospitalier Universitaire de Besancon","enrollment":222,"countries":["France"],"start_date":"2013-09-01","completion_date":"2017-01-01","last_update_date":"2018-04-05","source_url":"https://clinicaltrials.gov/study/NCT02116270","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:08.862442+00:00","last_seen_at":"2026-09-25T06:15:06.064+00:00","metadata":{"sex":"ALL","acronym":"IRIS","age_range":"18 Years to 85 Years","comparator":null,"organization":"Centre Hospitalier Universitaire de Besancon","interventions":["Blood sample"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Percentage of Cluster of Differentiation (CD) 4/8+ CD 57+ CD 28- lymphocytes (senescent lymphocytes) — 6 months","Telomerase Activity of T lymphocytes — 6 months","Level of phospho-histone 2AX (gH2AX) in peripheral blood T lymphocytes — 6 months","Proportion of Recent Thymic Emigrants (RTE) in peripheral blood T lymphocytes — 6 months","T-cell receptor excision circle (TREC) level in PBMC. — 6 months","Telomere length in T lymphocytes — 6 months"],"design_description":"NON RANDOMIZED · PARALLEL · OTHER · NONE","source_has_results":false},"controlled_terms":["Renal Failure","Blood sample"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: immunosenescence.","quality_checked_at":"2026-09-25T06:15:09.632521+00:00","duplicate_cluster_key":"id:nct02116270","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2013-09-01 to 2017-01-01","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:06.093Z","intervention":["Blood sample"],"participants":222,"study_design":"NON RANDOMIZED · PARALLEL · OTHER · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Percentage of Cluster of Differentiation (CD) 4/8+ CD 57+ CD 28- lymphocytes (senescent lymphocytes) — 6 months","Telomerase Activity of T lymphocytes — 6 months","Level of phospho-histone 2AX (gH2AX) in peripheral blood T lymphocytes — 6 months","Proportion of Recent Thymic Emigrants (RTE) in peripheral blood T lymphocytes — 6 months","T-cell receptor excision circle (TREC) level in PBMC. — 6 months","Telomere length in T lymphocytes — 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"immune-aging","is_published":true,"match_reasons":["Title contains controlled term: immunosenescence.","Title supplies longevity context: senescence.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Immune ageing","slug":"immune-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29419","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}