{"type":"trials","record":{"id":29421,"source_id":"clinicaltrials-gov","external_id":"NCT03489083","title":"Heat Shock Response is Blunted in Elderly Diabetic People But Recovered by Strength Training","brief_summary":"The aim of this study was to compare the heat shock response (HSR) between healthy middle-aged adults, healthy elderly adults and type 2 diabetic elderly people. In addition, considering the effects of strength exercise in promoting health, we aimed to test the effects of strength training over the HSR in diabetic elderly people. Thirty (19 females and 11 males) sedentary non-smoking participants volunteered for this study (11 healthy middle-age adults, 7 healthy old adults and 12 diabetic old subjects, previously diagnosed by their personal physicians). Firstly, venous blood samples were obtained from all participants to test the HSR. They were divided in three groups: healthy middle-age adults (45-59 y.o.), healthy elderly adults and elderly diabetic (\\> 60 y.o.). As we identify that diabetic people presented a poor HSR, we submit the diabetic group to a twelve-week resistance exercise training to verify if this intervention could improve the HS response. Diabetic subjects were randomly (1:1 block randomization) allocated in one of the two groups: Trained and Control (no training). Strength training was performed three times per week while the control group performed a \"placebo\" stretching/relaxing session once a week (for adherence purposes). Both interventions had twelve weeks of duration. To avoid any significant adaptation, all stretching exercises (for large muscle groups only) were performed at very low intensity without any significant discomfort. Supervised (by qualified sport and exercise scientists) exercise was performed in a gym on three non-consecutive days of the week. Each session lasted \\~60 min and consisted of a warm up, the resistance exercise training and a cool down. The training programme consisted of a combination of upper and lower body exercises using gym equipments, free weights and body weight as the primary resistance. The twelve weeks of strength training were divided into three mesocycles of four weeks each. Exercises included leg press, knee extensions and leg curls, biceps curls, triceps extensions, lat pull-downs, shoulder press, bench press and abdominal crunch. Before the start of the training period, subjects completed a familiarization session to practice the exercises they would further perform during the training sessions, where the exercise load was individually tested. The resistance training was performed using two to three sets per exercise at intensities between 12-15 repetition maximum-RM.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Federal University of Rio Grande do Sul","enrollment":30,"countries":["Brazil"],"start_date":"2016-02-01","completion_date":"2018-03-01","last_update_date":"2018-04-05","source_url":"https://clinicaltrials.gov/study/NCT03489083","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:08.862442+00:00","last_seen_at":"2026-09-25T06:00:07.808+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"45 Years to 85 Years","comparator":"No Training Group","organization":"Federal University of Rio Grande do Sul","interventions":["Strength training","No Training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Heat Shock Response Change. — Before and After twelve weeks of exercise training.","hs-CRP Change. — Before and After twelve weeks of exercise training.","Body composition Change. — Before and After twelve weeks of exercise training.","TNF-a Change. — Before and After twelve weeks of exercise training.","IL-10 Change. — Before and After twelve weeks of exercise training.","Visceral Adipose Tissue Change. — Before and After twelve weeks of exercise training."],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · NONE","source_has_results":false},"controlled_terms":["Type 2 Diabetes Mellitus","Aging","Strength training","No Training"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: strength training.","quality_checked_at":"2026-09-25T06:00:15.557161+00:00","duplicate_cluster_key":"id:nct03489083","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2016-02-01 to 2018-03-01","comparator":"No Training Group","confidence":"structured-source","population":"ALL · 45 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:00:07.885Z","intervention":["Strength training","No Training"],"participants":30,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Heat Shock Response Change. — Before and After twelve weeks of exercise training.","hs-CRP Change. — Before and After twelve weeks of exercise training.","Body composition Change. — Before and After twelve weeks of exercise training.","TNF-a Change. — Before and After twelve weeks of exercise training.","IL-10 Change. — Before and After twelve weeks of exercise training.","Visceral Adipose Tissue Change. — Before and After twelve weeks of exercise training."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: strength training.","Abstract contains controlled term: resistance training, strength training.","Source terminology contains: strength training.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29421","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}