{"type":"trials","record":{"id":29428,"source_id":"clinicaltrials-gov","external_id":"NCT01256840","title":"Long-term Caloric Restriction and Cellular Aging Markers","brief_summary":"The purpose of this study is to see whether people who have restricted the number of calories they eat for a long period of time, compared to normal-eating and obese people, have markers of cellular aging that look younger.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University of California, San Francisco","enrollment":71,"countries":["United States"],"start_date":"2010-12-01","completion_date":"2014-08-01","last_update_date":"2017-10-13","source_url":"https://clinicaltrials.gov/study/NCT01256840","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:08.862442+00:00","last_seen_at":"2026-09-25T06:05:20.497+00:00","metadata":{"sex":"ALL","acronym":"CRONA","age_range":"18 Years","comparator":null,"organization":"University of California, San Francisco","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Telomere Length — One day"],"design_description":null,"source_has_results":true},"controlled_terms":["Aging"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: caloric restriction.","quality_checked_at":"2026-09-25T06:05:21.960425+00:00","duplicate_cluster_key":"id:nct01256840","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2010-12-01 to 2014-08-01","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:20.518Z","intervention":[],"participants":71,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Telomere Length — One day"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"caloric-restriction","is_published":true,"match_reasons":["Title contains controlled term: caloric restriction.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Caloric restriction","slug":"caloric-restriction"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29428","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}