{"type":"trials","record":{"id":29450,"source_id":"clinicaltrials-gov","external_id":"NCT02921659","title":"Safety & Efficacy of Nicotinamide Riboside Supplementation for Improving Physiological Function in Middle-Aged and Older Adults","brief_summary":"The purpose of this study is to assess the efficacy of supplementation with the Nicotinamide Adenine Dinucleotide (NAD+) precursor compound, Nicotinamide Riboside (NR), for improving physiological function (vascular, motor, and cognitive) in healthy middle-aged and older adults.","overall_status":"Completed","phases":["PHASE1","PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"University of Colorado, Boulder","enrollment":30,"countries":["United States"],"start_date":"2015-04-01","completion_date":"2016-10-01","last_update_date":"2016-12-01","source_url":"https://clinicaltrials.gov/study/NCT02921659","editorial_summary":"A registered PHASE1, PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:08.862442+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"55 Years to 79 Years","comparator":"Placebo; Niagen™","organization":"University of Colorado, Boulder","interventions":["Niagen™","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Incidence of treatment emergent adverse events — 6 weeks","Endothelium Dependent Dilation — 6 weeks","Arterial Stiffness — 6 weeks","Cognitive Function — 6 weeks","Motor Function — 6 weeks","Systemic markers of oxidative stress and inflammation — 6 weeks"],"design_description":"RANDOMIZED · CROSSOVER · TREATMENT · DOUBLE","source_has_results":false},"controlled_terms":["Aging","Niagen™","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: nicotinamide riboside.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct02921659","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2015-04-01 to 2016-10-01","comparator":"Placebo; Niagen™","confidence":"structured-source","population":"ALL · 55 Years to 79 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.495Z","intervention":["Niagen™","Placebo"],"participants":30,"study_design":"RANDOMIZED · CROSSOVER · TREATMENT · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1, PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Incidence of treatment emergent adverse events — 6 weeks","Endothelium Dependent Dilation — 6 weeks","Arterial Stiffness — 6 weeks","Cognitive Function — 6 weeks","Motor Function — 6 weeks","Systemic markers of oxidative stress and inflammation — 6 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"nad-metabolism","is_published":true,"match_reasons":["Title contains controlled term: nicotinamide riboside.","Abstract contains controlled term: nad+, nicotinamide riboside.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"NAD metabolism","slug":"nad-metabolism"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29450","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}