{"type":"trials","record":{"id":29474,"source_id":"clinicaltrials-gov","external_id":"NCT01865435","title":"IN UTERO SMOKING AND PREMATURE CELLULAR SENESCENCE","brief_summary":"Actually, there is an increasing number of arguments for a premature origin of chronic adult's diseases, as the chronic obstructive pulmonary disease (COPD). Several factors interacting with the foetal or postnatal lung growth are associated with early and long-lasting respiratory functional changes susceptible to contribute very significantly to the arisen of a COPD in the adulthood. It is possible that these situations reflect phenomena of premature cellular senescence, recently involved in the physiopathology of the COPD. An in utero exposition to cigarette smoking is one of these situations, because it is known to induce, not only functional respiratory changes, but also multiple diseases in the child which could testify of cellular ageing phenomena. Our project aims to demonstrate that in utero smoking is associated with markers of premature cellular senescence in newborn children The study will be driven in human newborn child's, with comparison of the length of the telomeres in circulating lymphocytes (umbilical blood is collected), according to the exposure in in utero smoking and also according to the degree of hypotrophy. This study will be a pilot study completed by an animal experimental study.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Assistance Publique Hopitaux De Marseille","enrollment":40,"countries":["France"],"start_date":"2014-03-01","completion_date":"2015-04-01","last_update_date":"2015-10-01","source_url":"https://clinicaltrials.gov/study/NCT01865435","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:08.862442+00:00","last_seen_at":"2026-09-25T06:05:20.497+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"27 Days","comparator":null,"organization":"Assistance Publique Hopitaux De Marseille","interventions":["cord blood sample"],"registry_source":"ClinicalTrials.gov","outcome_measures":["cord blood samples — 12months"],"design_description":"NA · SINGLE GROUP · NONE","source_has_results":false},"controlled_terms":["Chronic Obstructive Pulmonary Disease","cord blood sample"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: cellular senescence.","quality_checked_at":"2026-09-25T06:05:21.960425+00:00","duplicate_cluster_key":"id:nct01865435","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2014-03-01 to 2015-04-01","comparator":null,"confidence":"structured-source","population":"ALL · 27 Days","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:20.520Z","intervention":["cord blood sample"],"participants":40,"study_design":"NA · SINGLE GROUP · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["cord blood samples — 12months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"senolytics","is_published":true,"match_reasons":["Title contains controlled term: cellular senescence.","Abstract contains controlled term: cellular senescence.","Title supplies longevity context: senescence.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Senolytics","slug":"senolytics"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29474","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}