{"type":"trials","record":{"id":29555,"source_id":"clinicaltrials-gov","external_id":"NCT01804049","title":"Metformin and Muscle in Insulin-resistant Older Veterans","brief_summary":"Sarcopenia is the loss of muscle mass, strength and function with aging and is associated with increased disability, falls and fractures. Older adults with diabetes and prediabetes are insulin resistant and have a higher risk of developing sarcopenia. This study examines the use of metformin, an antidiabetic drug, for preventing the development of sarcopenia in older adults with prediabetes.","overall_status":"Completed","phases":["PHASE1","PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"VA Office of Research and Development","enrollment":120,"countries":["United States"],"start_date":"2014-04-08","completion_date":"2018-08-31","last_update_date":"2020-02-11","source_url":"https://clinicaltrials.gov/study/NCT01804049","editorial_summary":"A registered PHASE1, PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:13.338836+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":"M&M","age_range":"65 Years","comparator":"Placebo; Metformin","organization":"VA Office of Research and Development","interventions":["metformin","placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Total Lean Mass From Baseline — 3 years","Change in Physical Performance - 400 Meter Walk Speed — 3 years","Change in Muscle Characteristics — 6 months"],"design_description":"RANDOMIZED · PARALLEL · OTHER · DOUBLE","source_has_results":true},"controlled_terms":["Prediabetes","metformin","placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: metformin.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct01804049","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2014-04-08 to 2018-08-31","comparator":"Placebo; Metformin","confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.889Z","intervention":["metformin","placebo"],"participants":120,"study_design":"RANDOMIZED · PARALLEL · OTHER · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1, PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Total Lean Mass From Baseline — 3 years","Change in Physical Performance - 400 Meter Walk Speed — 3 years","Change in Muscle Characteristics — 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Title contains controlled term: metformin.","Abstract contains controlled term: metformin.","Source terminology contains: metformin.","Abstract supplies longevity context: aging, older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","abstract context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29555","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}