{"type":"trials","record":{"id":29556,"source_id":"clinicaltrials-gov","external_id":"NCT02308228","title":"Metformin to Augment Strength Training Effective Response in Seniors (MASTERS)","brief_summary":"The purpose of this study is to determine whether a commonly prescribed drug, metformin, can enhance the benefits seen during resistance exercise such as increased muscle mass and strength.","overall_status":"Completed","phases":["EARLY_PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"Philip Kern","enrollment":109,"countries":["United States"],"start_date":"2015-01-14","completion_date":"2018-06-28","last_update_date":"2019-09-17","source_url":"https://clinicaltrials.gov/study/NCT02308228","editorial_summary":"A registered EARLY_PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:13.338836+00:00","last_seen_at":"2026-09-25T06:00:18.815+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":"Placebo, Sugar Pill","organization":"University of Kentucky","interventions":["Progressive Resistance Training","Metformin"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Percent Change in Type 2 Myofiber Cross Sectional Area — 16 weeks","Percent Change in Normal Density Muscle Size by Computed Tomography — 16 weeks"],"design_description":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · TRIPLE","source_has_results":true},"controlled_terms":["Aging","Progressive Resistance Training","Metformin"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: metformin.","quality_checked_at":"2026-09-25T06:00:19.43954+00:00","duplicate_cluster_key":"id:nct02308228","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2015-01-14 to 2018-06-28","comparator":"Placebo, Sugar Pill","confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:00:18.823Z","intervention":["Progressive Resistance Training","Metformin"],"participants":109,"study_design":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"EARLY_PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Percent Change in Type 2 Myofiber Cross Sectional Area — 16 weeks","Percent Change in Normal Density Muscle Size by Computed Tomography — 16 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Title contains controlled term: metformin.","Abstract contains controlled term: metformin.","Source terminology contains: metformin.","Source terminology supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","controlled context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29556","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}