{"type":"trials","record":{"id":29566,"source_id":"clinicaltrials-gov","external_id":"NCT02745886","title":"Metformin Induces a Dietary Restriction-like State in Human","brief_summary":"The fact that metformin treatment has been associated with reduced risk of cancer and cardiovascular disease raises the possibility of a beneficial role of metformin for other age-related diseases. The actions of metformin resemble the effects of calorie restriction (CR) to some extent, and microarray analyses have shown that metformin induces a gene expression profile that aligns with that of CR in animal. The aim of the study is to investigate whether metformin treatment can induce dietary restriction-like state in human. Sixty overweight subjects will be included in this study, and participants will be divided 3 groups (20 cases in each group)including metformin group (0.85, twice daily), standard diet group, and CR group. All subjects will be treated 6 months. At the end of this study, blood samples and muscle samples will be obtained.","overall_status":"Unknown","phases":["PHASE4"],"study_type":"INTERVENTIONAL","sponsor":"Xiang Guang-da","enrollment":60,"countries":["China"],"start_date":"2016-04-01","completion_date":"2016-12-01","last_update_date":"2016-04-26","source_url":"https://clinicaltrials.gov/study/NCT02745886","editorial_summary":"A registered PHASE4 study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:13.338836+00:00","last_seen_at":"2026-09-25T06:05:15.478+00:00","metadata":{"sex":"MALE","acronym":null,"age_range":"18 Years to 60 Years","comparator":"Standard diet group","organization":"Wuhan General Hospital of Guangzhou Military Command","interventions":["metformin 0.85 twice daily for 6 months","Calorie restriction"],"registry_source":"ClinicalTrials.gov","outcome_measures":["The differences of gene expression profile among 3 groups. — 6 months","The differences of insulin sensitivity in 3 groups — 6 months"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Overweight Subjects","Metformin","Aging","metformin 0.85 twice daily for 6 months","Calorie restriction"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: metformin.","quality_checked_at":"2026-09-25T06:05:18.114262+00:00","duplicate_cluster_key":"id:nct02745886","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2016-04-01 to 2016-12-01","comparator":"Standard diet group","confidence":"structured-source","population":"MALE · 18 Years to 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:15.516Z","intervention":["metformin 0.85 twice daily for 6 months","Calorie restriction"],"participants":60,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE4","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["The differences of gene expression profile among 3 groups. — 6 months","The differences of insulin sensitivity in 3 groups — 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Title contains controlled term: metformin.","Abstract contains controlled term: metformin.","Source terminology contains: metformin.","Abstract supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","abstract context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29566","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}