{"type":"trials","record":{"id":29567,"source_id":"clinicaltrials-gov","external_id":"NCT02511665","title":"Metformin And Longevity","brief_summary":"This is a randomized, placebo-controlled, double-blind, window of opportunity study investigating the biological mechanism of metformin in prostate cancer.","overall_status":"Unknown","phases":["PHASE4"],"study_type":"INTERVENTIONAL","sponsor":"Guy's and St Thomas' NHS Foundation Trust","enrollment":185,"countries":["United Kingdom"],"start_date":"2015-07-01","completion_date":"2017-07-01","last_update_date":"2015-07-30","source_url":"https://clinicaltrials.gov/study/NCT02511665","editorial_summary":"A registered PHASE4 study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:13.338836+00:00","last_seen_at":"2026-09-25T06:05:31.63+00:00","metadata":{"sex":"MALE","acronym":"METAL","age_range":"18 Years","comparator":"Placebo","organization":"Guy's and St Thomas' NHS Foundation Trust","interventions":["Metformin","PET-MRI Scan","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Assessment of the difference in expression levels of markers of the FASN/AMPK pathway pre and post treatment between th…"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · QUADRUPLE","source_has_results":false},"controlled_terms":["Prostate Cancer","Metformin","PET-MRI Scan","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: metformin.","quality_checked_at":"2026-09-25T06:05:33.370492+00:00","duplicate_cluster_key":"id:nct02511665","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2015-07-01 to 2017-07-01","comparator":"Placebo","confidence":"structured-source","population":"MALE · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:31.650Z","intervention":["Metformin","PET-MRI Scan","Placebo"],"participants":185,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE4","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Assessment of the difference in expression levels of markers of the FASN/AMPK pathway pre and post treatment between th…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Title contains controlled term: metformin.","Abstract contains controlled term: metformin.","Source terminology contains: metformin.","Title supplies longevity context: longevity.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29567","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}