{"type":"trials","record":{"id":29625,"source_id":"clinicaltrials-gov","external_id":"NCT02140983","title":"Effects of Liraglutide on Hippocampal Structure and Function in Aging Adults With Prediabetes","brief_summary":"The purpose of this study is to evaluate the effects of liraglutide on the memory and attention of people with insulin resistance. Liraglutide is a medication that makes the body more sensitive to insulin, and therefore may allow it to manage sugar more effectively. The investigators are looking specifically at a region of the brain that is associated with memory and attention, called the hippocampus, in order to see whether treatment this treatment will change performance on memory and attention tasks. The investigators are also taking an MRI of the brain to see whether there are changes to the size and shape of the hippocampus after treatment. All subjects in this study will be 50-70 years old and have pre- diabetes. Half of all subjects will have a family history of dementia, while the other half will not.","overall_status":"Completed","phases":["PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"Stanford University","enrollment":41,"countries":["United States"],"start_date":"2013-08-01","completion_date":"2017-02-01","last_update_date":"2018-01-25","source_url":"https://clinicaltrials.gov/study/NCT02140983","editorial_summary":"A registered PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:14.417495+00:00","last_seen_at":"2026-09-25T06:00:20.219+00:00","metadata":{"sex":"ALL","acronym":"LGT","age_range":"50 Years to 70 Years","comparator":"Liraglutide; Placebo","organization":"Stanford University","interventions":["Liraglutide","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Cognitive Outcomes — Change from Baseline to 3 months","OGTT — Change from Baseline to 3 months"],"design_description":"RANDOMIZED · PARALLEL · OTHER · TRIPLE","source_has_results":false},"controlled_terms":["Insulin Resistance","Dementia","Liraglutide","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: liraglutide.","quality_checked_at":"2026-09-25T06:00:20.957351+00:00","duplicate_cluster_key":"id:nct02140983","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2013-08-01 to 2017-02-01","comparator":"Liraglutide; Placebo","confidence":"structured-source","population":"ALL · 50 Years to 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:00:20.230Z","intervention":["Liraglutide","Placebo"],"participants":41,"study_design":"RANDOMIZED · PARALLEL · OTHER · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Cognitive Outcomes — Change from Baseline to 3 months","OGTT — Change from Baseline to 3 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"glp-1-therapies","is_published":true,"match_reasons":["Title contains controlled term: liraglutide.","Abstract contains controlled term: liraglutide.","Source terminology contains: liraglutide.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"GLP-1 therapies","slug":"glp-1-therapies"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29625","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}