{"type":"trials","record":{"id":29827,"source_id":"clinicaltrials-gov","external_id":"NCT07731529","title":"Vivifrail Exercise Program in Nonagenarians: Effects on Function, Muscle, and Cognition","brief_summary":"This randomized clinical trial investigates the effects of a home-based multicomponent exercise program (Vivifrail) on physical function, muscle morphology, and cognition in community-dwelling adults aged 90 years and older. Participants are randomized into three groups: Vivifrail at least twice a week, Vivifrail at least three times a week, or a control group. Outcomes are assessed at baseline, 12 weeks, and 24 weeks. The primary outcome is physical function measured by the Short Physical Performance Battery (SPPB).","overall_status":"Enrolling By Invitation","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Federal University of Rio Grande do Sul","enrollment":54,"countries":["Brazil"],"start_date":"2026-07-29","completion_date":"2027-11-01","last_update_date":"2026-09-03","source_url":"https://clinicaltrials.gov/study/NCT07731529","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Enrolling By Invitation. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:16.485702+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":"Vivifrail","age_range":"90 Years","comparator":"Control (GC)","organization":"Federal University of Rio Grande do Sul","interventions":["Vivifrail multicomponent exercise program"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in physical function measured by the Short Physical Performance Battery (SPPB) total score — Baseline (T0), 12 w…","Mobility - Timed Up and Go (TUG) — Baseline (T0), 12 weeks (T1), and 24 weeks (T2)","Mobility under dual task - Cognitive TUG and dual-task cost (DTC%) · — Baseline (T0), 12 weeks (T1), and 24 weeks (T2)).","Handgrip strength — Baseline (T0), 12 weeks (T1), and 24 weeks (T2)).","Lower-limb muscle power - Five-times sit-to-stand — Baseline (T0), 12 weeks (T1), and 24 weeks (T2)).","Gait speed — aseline (T0), 12 weeks (T1), and 24 weeks (T2)).","Balance — Baseline (T0), 12 weeks (T1), and 24 weeks (T2)).","Change in Vastus Lateralis Muscle Thickness — Baseline (T0), 12 weeks (T1), and 24 weeks (T2)","Change in Vastus Lateralis Echo Intensity (Muscle Quality) — Baseline (T0), 12 weeks (T1), and 24 weeks (T2)","Cognition - Mini-Mental State Examination (MMSE) — Baseline (T0), 12 weeks (T1), and 24 weeks (T2)","Change in Vivifrail functional category — Baseline (T0), 12 weeks (T1), and 24 weeks (T2)"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","source_has_results":false},"controlled_terms":["Frailty","Aging","Cognitive Decline","Vivifrail multicomponent exercise program"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct07731529","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-07-29 to 2027-11-01","comparator":"Control (GC)","confidence":"structured-source","population":"ALL · 90 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.391Z","intervention":["Vivifrail multicomponent exercise program"],"participants":54,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in physical function measured by the Short Physical Performance Battery (SPPB) total score — Baseline (T0), 12 w…","Mobility - Timed Up and Go (TUG) — Baseline (T0), 12 weeks (T1), and 24 weeks (T2)","Mobility under dual task - Cognitive TUG and dual-task cost (DTC%) · — Baseline (T0), 12 weeks (T1), and 24 weeks (T2)).","Handgrip strength — Baseline (T0), 12 weeks (T1), and 24 weeks (T2)).","Lower-limb muscle power - Five-times sit-to-stand — Baseline (T0), 12 weeks (T1), and 24 weeks (T2)).","Gait speed — aseline (T0), 12 weeks (T1), and 24 weeks (T2)).","Balance — Baseline (T0), 12 weeks (T1), and 24 weeks (T2)).","Change in Vastus Lateralis Muscle Thickness — Baseline (T0), 12 weeks (T1), and 24 weeks (T2)","Change in Vastus Lateralis Echo Intensity (Muscle Quality) — Baseline (T0), 12 weeks (T1), and 24 weeks (T2)","Cognition - Mini-Mental State Examination (MMSE) — Baseline (T0), 12 weeks (T1), and 24 weeks (T2)","Change in Vivifrail functional category — Baseline (T0), 12 weeks (T1), and 24 weeks (T2)"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Source terminology contains: exercise.","Title supplies longevity context: frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/29827","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}