{"type":"trials","record":{"id":30029,"source_id":"clinicaltrials-gov","external_id":"NCT06856720","title":"NMES, Exercise, and Glycemic Control in Older Adults With Type 2 Diabetes","brief_summary":"Adults aged 60 years and older with type 2 diabetes living in nursing homes may experience difficulty participating in conventional exercise programs because of frailty, mobility limitations, or chronic health conditions. This randomized controlled trial compares three 12-week non-pharmacological interventions for glycemic management: neuromuscular electrical stimulation (NMES), supervised combined aerobic and resistance exercise, and a structured health literacy intervention. Participants will be randomly assigned to one of the three groups. The primary outcome is weekly mean fasting capillary glucose. Secondary outcomes include health-related quality of life, treatment satisfaction, adherence, and safety. The study aims to identify feasible and clinically relevant strategies for improving diabetes management in institutionalized older adults.","overall_status":"Enrolling By Invitation","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Salamanca","enrollment":75,"countries":["Portugal"],"start_date":"2025-10-27","completion_date":"2026-10-30","last_update_date":"2026-08-10","source_url":"https://clinicaltrials.gov/study/NCT06856720","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Enrolling By Invitation. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:16.485702+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":"NMES4GlyCon","age_range":"60 Years","comparator":"Combined Aerobic and Resistance Exercise","organization":"University of Salamanca","interventions":["Neuromuscular Electrical Stimulation","Combined Aerobic and Resistance Exercise","Health Literacy Education"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Weekly Mean Fasting Capillary Glucose — Baseline, weekly during the 12-week intervention period, and at 30-, 60-, and 9…","Audit of Diabetes-Dependent Quality of Life (ADDQoL-18) — Baseline, Week 12 (post-intervention), Day 30 follow-up, Day…","Overall Treatment Satisfaction (3-item adapted questionnaire based on the Diabetes Treatment Satisfaction Questionnaire…","Perceived Frequency of Hyperglycemia (3-item adapted questionnaire based on the Diabetes Treatment Satisfaction Questio…","Perceived Frequency of Hypoglycemia (3-item adapted questionnaire based on the Diabetes Treatment Satisfaction Question…","Treatment Adherence — Throughout 12-week intervention period"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","source_has_results":false},"controlled_terms":["Type 2 Diabetes Mellitus","Hyperglycemia Due to Type 2 Diabetes Mellitus","Aging","Neuromuscular Electrical Stimulation","Combined Aerobic and Resistance Exercise","Health Literacy Education"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct06856720","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-10-27 to 2026-10-30","comparator":"Combined Aerobic and Resistance Exercise","confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.399Z","intervention":["Neuromuscular Electrical Stimulation","Combined Aerobic and Resistance Exercise","Health Literacy Education"],"participants":75,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Weekly Mean Fasting Capillary Glucose — Baseline, weekly during the 12-week intervention period, and at 30-, 60-, and 9…","Audit of Diabetes-Dependent Quality of Life (ADDQoL-18) — Baseline, Week 12 (post-intervention), Day 30 follow-up, Day…","Overall Treatment Satisfaction (3-item adapted questionnaire based on the Diabetes Treatment Satisfaction Questionnaire…","Perceived Frequency of Hyperglycemia (3-item adapted questionnaire based on the Diabetes Treatment Satisfaction Questio…","Perceived Frequency of Hypoglycemia (3-item adapted questionnaire based on the Diabetes Treatment Satisfaction Question…","Treatment Adherence — Throughout 12-week intervention period"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Source terminology contains: exercise.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/30029","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}