{"type":"trials","record":{"id":30032,"source_id":"clinicaltrials-gov","external_id":"NCT05007353","title":"The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) Study","brief_summary":"A study in Finland found that a multidomain intervention of physical activity, nutritional guidance, cognitive training, social activities and management of vascular risk factors slowed cognitive decline in healthy older adults at increased risk of cognitive decline. A 6-month pilot study was initiated in Singapore, which demonstrated the cultural feasibility and practicality of the FINGER interventions and a set of locally adapted interventions in an Asian population. The SINGER study is a 2-year randomized controlled trial that aims to test the efficacy and safety of these lifestyle changes, including diet and cardiovascular risk factor management, cognitive and physical exercises, in delaying cognitive decline in older adults at risk of dementia.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"National University of Singapore","enrollment":1212,"countries":["Singapore"],"start_date":"2021-08-23","completion_date":"2025-12-29","last_update_date":"2026-08-10","source_url":"https://clinicaltrials.gov/study/NCT05007353","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:16.485702+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"ALL","acronym":"SINGER","age_range":"60 Years to 80 Years","comparator":null,"organization":"National University of Singapore","interventions":["Structured Lifestyle Intervention","Self-Guided Intervention"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Global Cognition — Up to 2 years","Episodic Memory — Up to 2 years","Executive Function — Up to 2 years","Processing Speed — Up to 2 years","Clinical Dementia Rating-Sum of Boxes (CDR-SB) — Up to 2 years","Alzheimer's Disease Cooperative Study Activities of Daily Living-Mild Cognitive Impairment-Activities of Daily Living I…","The Geriatric Depression Scale (GDS) — Up to 2 years","Global Physical Activity Questionnaire (GPAQ) — Up to 2 years","Prospective-Retrospective Memory Questionnaire — Up to 2 years","Pittsburgh Sleep Quality Index (PSQI) — Up to 2 years","Leisure-Time Activities Questionnaire — Up to 2 years","Physical Performance Test (PPT) — Up to 2 years","Quality of Life Questionnaire (15D) — Up to 2 years","36-Item Short Form Survey (SF-36) — Up to 2 years","Resource Use Inventory (RUI) — Up to 2 years","Height — Up to 2 years","Weight — Up to 2 years","Hip and waist circumference — Up to 2 years","Changes in Blood Pressure — Up to 2 years","Changes in Lipid Profile — Up to 2 years"],"design_description":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · SINGLE","source_has_results":false},"controlled_terms":["Cognitive Impairment","Alzheimer Disease","Vascular Cognitive Impairment","Dementia","Brain Diseases","Central Nervous System Diseases","Nervous System Diseases","Neurocognitive Disorders","Mental Disorders","Cognition Disorder","Structured Lifestyle Intervention","Self-Guided Intervention"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct05007353","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-08-23 to 2025-12-29","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.396Z","intervention":["Structured Lifestyle Intervention","Self-Guided Intervention"],"participants":1212,"study_design":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Global Cognition — Up to 2 years","Episodic Memory — Up to 2 years","Executive Function — Up to 2 years","Processing Speed — Up to 2 years","Clinical Dementia Rating-Sum of Boxes (CDR-SB) — Up to 2 years","Alzheimer's Disease Cooperative Study Activities of Daily Living-Mild Cognitive Impairment-Activities of Daily Living I…","The Geriatric Depression Scale (GDS) — Up to 2 years","Global Physical Activity Questionnaire (GPAQ) — Up to 2 years","Prospective-Retrospective Memory Questionnaire — Up to 2 years","Pittsburgh Sleep Quality Index (PSQI) — Up to 2 years","Leisure-Time Activities Questionnaire — Up to 2 years","Physical Performance Test (PPT) — Up to 2 years","Quality of Life Questionnaire (15D) — Up to 2 years","36-Item Short Form Survey (SF-36) — Up to 2 years","Resource Use Inventory (RUI) — Up to 2 years","Height — Up to 2 years","Weight — Up to 2 years","Hip and waist circumference — Up to 2 years","Changes in Blood Pressure — Up to 2 years","Changes in Lipid Profile — Up to 2 years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/30032","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}