{"type":"trials","record":{"id":30045,"source_id":"clinicaltrials-gov","external_id":"NCT07643064","title":"Multicomponent Exercise and Comprehensive Geriatric Assessment Program (FRAIL+AP) for Frail Older Adults in Primary Care","brief_summary":"Frailty is a multidimensional clinical syndrome associated with increased vulnerability to adverse health outcomes in older adults. Despite strong evidence supporting multicomponent exercise interventions, their implementation in primary care settings remains limited. This randomized controlled trial aims to evaluate the efficacy of the FRAIL+AP program, which integrates Comprehensive Geriatric Assessment (CGA) with a 12-week multicomponent exercise intervention, including visual-spatial gait retraining using the Tapiz Fisior system. The study will assess whether this intervention improves frailty status, physical performance, and functional independence, while reducing falls among community-dwelling older adults compared to standard care.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Alberto Bermejo Franco","enrollment":200,"countries":["Spain"],"start_date":"2026-05-28","completion_date":"2026-12-31","last_update_date":"2026-08-07","source_url":"https://clinicaltrials.gov/study/NCT07643064","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:16:16.485702+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":"FRAIL+AP","age_range":"70 Years","comparator":"Usual Care","organization":"Universidad Europea de Madrid","interventions":["FRAIL+AP Program","Usual Care"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in frailty status measured by the FRAIL Scale — Baseline and 12 weeks","Change in physical performance measured by the Short Physical Performance Battery (SPPB) — Baseline and 12 weeks","Incidence of Falls — Baseline and 12 weeks","Musculoskeletal Pain Intensity — Baseline and 12 weeks","Mood and Affective Status — Baseline and 12 weeks","Functional Independence — Baseline and 12 weeks","Nutritional Status — Baseline and 12 weeks","Handgrip Strength — Baseline and 12 weeks","Comorbidity Burden — Baseline and 12 weeks","Healthcare Resource Utilization — Baseline and 12 weeks"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","source_has_results":false},"controlled_terms":["Frail Elderly","FRAIL+AP Program","Usual Care"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct07643064","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-05-28 to 2026-12-31","comparator":"Usual Care","confidence":"structured-source","population":"ALL · 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.400Z","intervention":["FRAIL+AP Program","Usual Care"],"participants":200,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in frailty status measured by the FRAIL Scale — Baseline and 12 weeks","Change in physical performance measured by the Short Physical Performance Battery (SPPB) — Baseline and 12 weeks","Incidence of Falls — Baseline and 12 weeks","Musculoskeletal Pain Intensity — Baseline and 12 weeks","Mood and Affective Status — Baseline and 12 weeks","Functional Independence — Baseline and 12 weeks","Nutritional Status — Baseline and 12 weeks","Handgrip Strength — Baseline and 12 weeks","Comorbidity Burden — Baseline and 12 weeks","Healthcare Resource Utilization — Baseline and 12 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Title supplies longevity context: frail, older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/30045","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}